Snapshots of the reaction coordinate of a thermophilic 2′-deoxyribonucleoside/ribonucleoside transferase

P Tang, CJ Harding, AL Dickson, RG da Silva… - ACS …, 2024 - ACS Publications
Nucleosides are ubiquitous to life and are required for the synthesis of DNA, RNA, and other
molecules crucial for cell survival. Despite the notoriously difficult organic synthesis of …

Reply to Comment on:“Computer Simulations Reveal an Entirely Entropic Activation Barrier for the Chemical Step in a Designer Enzyme”

J Åqvist - ACS Catalysis, 2023 - ACS Publications
Lear et al. question the kinetic model presented by us for the 1A53-2.5 designer enzyme
[Åqvist. ACS Catal. 2022, 12, 1452− 1460], specifically arguing that there should be a …

Thermal Sensitivity of the Enzymatic Activity of β-Glucosidase: Simulations Lend Mechanistic Insights into Experimental Observations

S Sahu, S Ghosh, SK Sinha, S Datta, N Sengupta - Biochemistry, 2023 - ACS Publications
A crucial prerequisite for industrial applications of enzymes is the maintenance of specific
activity across wide thermal ranges. β-Glucosidase (EC 3.2. 1.21) is an essential enzyme for …

Metalloenzyme-inspired approach to the design and applications of phosphatase-mimetic nanozymes. Bridging the inorganic and organic worlds

P Janoš - Environmental Science: Nano, 2024 - pubs.rsc.org
Nanozymes were introduced approximately 15 years ago as inorganic materials capable of
mimicking the catalytic abilities of natural (protein-based) enzymes. While the catalytic …

Computational Analysis of Heat Capacity Effects in Protein–Ligand Binding

L Koenekoop, J Åqvist - Journal of Chemical Theory and …, 2024 - ACS Publications
Heat capacity effects in protein–ligand binding as measured by calorimetric experiments
have recently attracted considerable attention, particularly in the field of enzyme inhibitor …

A Multienzyme Cascade Pathway Immobilized in a Hydrogen‐Bonded Organic Framework for the Conversion of CO2

R Pei, J Liu, C Jing, M Zhang - Small, 2024 - Wiley Online Library
The reduction of carbon dioxide to valuable chemicals through enzymatic processes is
regarded as a promising approach for the reduction of carbon dioxide emissions. In this …

Construction and enzymatic characterization of a monomeric variant of dimeric amylosucrase from Deinococcus geothermalis

JS Oh, YS So, S Hong, SH Yoo, CS Park… - International Journal of …, 2025 - Elsevier
Abstract Amylosucrase (ASase; EC 2.4. 1.4), a member of glycoside hydrolase family 13
(GH13), produces α-1, 4-glucans and sucrose isomers using sucrose as its sole substrate …

Physics-based Modeling in the New Era of Enzyme Engineering

C Jurich, Q Shao, X Ran, Z Yang - 2024 - chemrxiv.org
Enzyme engineering techniques optimize enzymes to synthesize value-added chemicals,
degrade environmental pollutants, and improve therapeutics. The field is entering a new era …

Efecto de temperatura y concentración de celulasa en la obtención de azúcares reductores de cáscara de papa nativa (Solanum tuberosum)

MO Vela Horna - 2024 - dspace.unitru.edu.pe
El uso y aprovechamiento de residuos vegetales es de gran importancia, sobre todo si en la
actualidad se fomenta la economía circular. En tal sentido, este trabajo tuvo por objetivo …

Biological catalyst evolution of enzymatic biofuel cells

W Liu, L Zhang - Biofuel Cells, 2024 - Elsevier
Biological catalysts, which encompass enzymes, organelles, and microbes, constitute
indispensable components within the realm of biofuel cells. Among these, enzymes hold a …