Mesenchymal stem cell-derived secretome: a potential therapeutic option for autoimmune and immune-mediated inflammatory diseases

G Műzes, F Sipos - Cells, 2022 - mdpi.com
Immune-mediated inflammatory diseases (IMIDs) encompass several entities such as
“classic” autoimmune disorders or immune-mediated diseases with autoinflammatory …

Applications of extracellular vesicles in nervous system disorders: an overview of recent advances

SU Khan, MI Khan, MU Khan, NM Khan, S Bungau… - Bioengineering, 2022 - mdpi.com
Diseases affecting the brain and spinal cord fall under the umbrella term “central nervous
system disease”. Most medications used to treat or prevent chronic diseases of the central …

Roles of extracellular vesicles associated non-coding RNAs in Diabetes Mellitus

BR Gauthier, N Cobo-Vuilleumier… - Frontiers in …, 2022 - frontiersin.org
Extracellular vesicles (EVs), especially exosomes (50 to 150 nm), have been shown to play
important roles in a wide range of physiological and pathological processes, including …

Stem cell-and cell-based therapies for ischemic stroke

DC Nistor-Cseppentö, MC Jurcău, A Jurcău… - Bioengineering, 2022 - mdpi.com
Stroke is the second cause of disability worldwide as it is expected to increase its incidence
and prevalence. Despite efforts to increase the number of patients eligible for recanalization …

Extracellular vesicles in sickle cell disease: a promising tool

Y Lamarre, E Nader, P Connes, M Romana, Y Garnier - Bioengineering, 2022 - mdpi.com
Sickle cell disease (SCD) is the most common hemoglobinopathy worldwide. It is
characterized by an impairment of shear stress-mediated vasodilation, a pro-coagulant, and …

The impact of environmental contaminants on extracellular vesicles and their key molecular regulators: A literature and database‐driven review

CK Carberry, JE Rager - Environmental and molecular …, 2023 - Wiley Online Library
Exposure to environmental chemicals is now well recognized as a significant factor
contributing to the global burden of disease; however, there remain critical gaps in …

Exosomes in transplantation: role in allograft rejection, diagnostic biomarker, and therapeutic potential

PB Saravanan, J Kalivarathan, F Khan, R Shah… - Life Sciences, 2023 - Elsevier
Abstract Exosomes are 50–200 nm-sized extracellular vesicles that are secreted by cells to
transfer signals and communicate with other cells. Recent research has revealed that …

Extracellular vesicles derived from stressed beta cells mediate monocyte activation and contribute to islet inflammation

MC Dekkers, JM Lambooij, X Pu… - Frontiers in …, 2024 - frontiersin.org
Objective Beta cell destruction in type 1 diabetes (T1D) results from the combined effect of
inflammation and recurrent autoimmunity. In recent years, the role played by beta cells in the …

Mesenchymal stem cells: generalities and clinical significance in feline and canine medicine

M Baouche, M Ochota, Y Locatelli, P Mermillod… - Animals, 2023 - mdpi.com
Simple Summary Veterinary regenerative medicine is an area of active research in which
mesenchymal stem cells are applied. Mesenchymal stem cells (MSCs) are cells that can be …

Fighting fire with fire: exosomes and acute pancreatitis-associated acute lung injury

Q Yang, Y Luo, B Lan, X Dong, Z Wang, P Ge, G Zhang… - Bioengineering, 2022 - mdpi.com
Acute pancreatitis (AP) is a prevalent clinical condition of the digestive system, with a
growing frequency each year. Approximately 20% of patients suffer from severe acute …