Forging a functional cure for HIV: transcription regulators and inhibitors
S Mediouni, S Lyu, SM Schader, ST Valente - Viruses, 2022 - mdpi.com
Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is
not curative. The major barrier to finding a definitive cure for HIV is our inability to identify …
not curative. The major barrier to finding a definitive cure for HIV is our inability to identify …
Transcription: insights from the HIV-1 promoter
E Ne, RJ Palstra, T Mahmoudi - International review of cell and molecular …, 2018 - Elsevier
In this review, we cover transcription regulation of human immunodeficiency virus type 1
(HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research …
(HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research …
Presence of Tat and transactivation response element in spinal fluid despite antiretroviral therapy
Objective: The aim of this study was to measure the protein concentration and biological
activity of HIV-1 Tat in cerebrospinal fluid (CSF) of individuals on suppressive antiretroviral …
activity of HIV-1 Tat in cerebrospinal fluid (CSF) of individuals on suppressive antiretroviral …
USP7 deubiquitinase controls HIV-1 production by stabilizing Tat protein
Deubiquitinases (DUBs) are key regulators of complex cellular processes. HIV-1 Tat is
synthesized early after infection and is mainly responsible for enhancing viral production …
synthesized early after infection and is mainly responsible for enhancing viral production …
Proteasomal degradation machinery: favorite target of HIV-1 proteins
Proteasomal degradation pathways play a central role in regulating a variety of protein
functions by controlling not only their turnover but also the physiological behavior of the cell …
functions by controlling not only their turnover but also the physiological behavior of the cell …
Post-translational modification-based regulation of HIV replication
L Chen, OT Keppler, C Schölz - Frontiers in Microbiology, 2018 - frontiersin.org
Human immunodeficiency virus (HIV) relies heavily on the host cellular machinery for
production of viral progeny. To exploit cellular proteins for replication and to overcome host …
production of viral progeny. To exploit cellular proteins for replication and to overcome host …
Alteration of cell junctions during viral infection
D Dong, W Xie, M Liu - Thoracic cancer, 2020 - Wiley Online Library
Cell junctions serve as a protective barrier for cells and provide an important channel for
information transmission between cells and the surrounding environment. Viruses are …
information transmission between cells and the surrounding environment. Viruses are …
USP7 manipulation by viral proteins
A Bojagora, V Saridakis - Virus research, 2020 - Elsevier
Abstract Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays
critical roles in the regulation of many cellular processes including epigenetics, tumour …
critical roles in the regulation of many cellular processes including epigenetics, tumour …
Uhrf1 suppresses HIV-1 transcription and promotes HIV-1 latency by competing with p-tefb for ubiquitination-proteasomal degradation of tat
T Liang, Q Zhang, Z Wu, P Chen, Y Huang, S Liu, L Li - MBio, 2021 - Am Soc Microbiol
ABSTRACT HIV-1 remains incurable due to viral reservoirs, which lead to durably latent HIV
infection. Identifying novel host factors and deciphering the molecular mechanisms involved …
infection. Identifying novel host factors and deciphering the molecular mechanisms involved …
Implication of different HIV-1 genes in the modulation of autophagy
Z Liu, Y Xiao, C Torresilla, É Rassart, B Barbeau - Viruses, 2017 - mdpi.com
Autophagy is a complex cellular degradation pathway, which plays important roles in the
regulation of several developmental processes, cellular stress responses, and immune …
regulation of several developmental processes, cellular stress responses, and immune …