Carbohydrate-based macromolecular biomaterials

L Su, Y Feng, K Wei, X Xu, R Liu, G Chen - Chemical Reviews, 2021 - ACS Publications
Carbohydrates are the most abundant and one of the most important biomacromolecules in
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …

Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands

S Cecioni, A Imberty, S Vidal - Chemical reviews, 2015 - ACS Publications
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

A Muñoz, D Sigwalt, BM Illescas, J Luczkowiak… - Nature …, 2016 - nature.com
The use of multivalent carbohydrate compounds to block cell-surface lectin receptors is a
promising strategy to inhibit the entry of pathogens into cells and could lead to the discovery …

From carbohydrate leads to glycomimetic drugs

B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …

Glycopolymer probes of signal transduction

LL Kiessling, JC Grim - Chemical Society Reviews, 2013 - pubs.rsc.org
Glycans are key participants in biological processes ranging from reproduction to cellular
communication to infection. Revealing glycan roles and the underlying molecular …

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

A Nanbo, M Imai, S Watanabe, T Noda… - PLoS …, 2010 - journals.plos.org
Ebolavirus (EBOV) is an enveloped, single-stranded, negative-sense RNA virus that causes
severe hemorrhagic fever with mortality rates of up to 90% in humans and nonhuman …

Design and creativity in synthesis of multivalent neoglycoconjugates

YM Chabre, R Roy - Advances in carbohydrate chemistry and biochemistry, 2010 - Elsevier
From the authors' opinion, this chapter constitutes a modest extension of the seminal and
inspiring contribution of Stowell and Lee on neoglycoconjugates published in this series [CP …

How C‐type lectins detect pathogens

A Cambi, M Koopman, CG Figdor - Cellular microbiology, 2005 - Wiley Online Library
Glycosylation of proteins has proven extremely important in a variety of cellular processes,
including enzyme trafficking, tissue homing and immune functions. In the past decade …

Cell surface biology mediated by low affinity multivalent protein–glycan interactions

BE Collins, JC Paulson - Current opinion in chemical biology, 2004 - Elsevier
Glycan-binding proteins mediate diverse aspects of cell biology including pathogen
recognition of host cells, cell trafficking, endocytosis and modulation of cell signaling. This is …

Pathogenesis of filoviral haemorrhagic fevers

S Mahanty, M Bray - The Lancet infectious diseases, 2004 - thelancet.com
The filoviruses, marburgvirus and ebolavirus, cause epidemics of haemorrhagic fever with
high casefatality rates. The severe illness results from a complex of pathogenetic …