Carbohydrate-based macromolecular biomaterials
Carbohydrates are the most abundant and one of the most important biomacromolecules in
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …
Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection
The use of multivalent carbohydrate compounds to block cell-surface lectin receptors is a
promising strategy to inhibit the entry of pathogens into cells and could lead to the discovery …
promising strategy to inhibit the entry of pathogens into cells and could lead to the discovery …
From carbohydrate leads to glycomimetic drugs
B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …
and as structural building blocks, they are fundamental constituents of every cell surface …
Glycopolymer probes of signal transduction
LL Kiessling, JC Grim - Chemical Society Reviews, 2013 - pubs.rsc.org
Glycans are key participants in biological processes ranging from reproduction to cellular
communication to infection. Revealing glycan roles and the underlying molecular …
communication to infection. Revealing glycan roles and the underlying molecular …
Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner
A Nanbo, M Imai, S Watanabe, T Noda… - PLoS …, 2010 - journals.plos.org
Ebolavirus (EBOV) is an enveloped, single-stranded, negative-sense RNA virus that causes
severe hemorrhagic fever with mortality rates of up to 90% in humans and nonhuman …
severe hemorrhagic fever with mortality rates of up to 90% in humans and nonhuman …
Design and creativity in synthesis of multivalent neoglycoconjugates
YM Chabre, R Roy - Advances in carbohydrate chemistry and biochemistry, 2010 - Elsevier
From the authors' opinion, this chapter constitutes a modest extension of the seminal and
inspiring contribution of Stowell and Lee on neoglycoconjugates published in this series [CP …
inspiring contribution of Stowell and Lee on neoglycoconjugates published in this series [CP …
How C‐type lectins detect pathogens
Glycosylation of proteins has proven extremely important in a variety of cellular processes,
including enzyme trafficking, tissue homing and immune functions. In the past decade …
including enzyme trafficking, tissue homing and immune functions. In the past decade …
Cell surface biology mediated by low affinity multivalent protein–glycan interactions
BE Collins, JC Paulson - Current opinion in chemical biology, 2004 - Elsevier
Glycan-binding proteins mediate diverse aspects of cell biology including pathogen
recognition of host cells, cell trafficking, endocytosis and modulation of cell signaling. This is …
recognition of host cells, cell trafficking, endocytosis and modulation of cell signaling. This is …
Pathogenesis of filoviral haemorrhagic fevers
S Mahanty, M Bray - The Lancet infectious diseases, 2004 - thelancet.com
The filoviruses, marburgvirus and ebolavirus, cause epidemics of haemorrhagic fever with
high casefatality rates. The severe illness results from a complex of pathogenetic …
high casefatality rates. The severe illness results from a complex of pathogenetic …