Improving pharmaceutical product development and manufacturing: impact on cost of drug development and cost of goods sold of pharmaceuticals

P Suresh, PK Basu - Journal of Pharmaceutical Innovation, 2008 - Springer
It is not commonly understood that one of the largest components of the overall cost of
bringing a new drug to the market is the cost of product development. Cost of product …

The impact of serialisation on operational efficiency and productivity in pharmaceutical sites: A literature review

D O'Mahony, O McDermott, A Lynch… - Cogent …, 2023 - Taylor & Francis
Serialization technology was introduced to protect the pharmaceutical supply chain from
falsified and substandard medicines infiltration. The implementation of serialization systems …

Making do in making drugs: innovation policy and pharmaceutical manufacturing

W Price, II Nicholson - BCL Rev., 2014 - HeinOnline
Despite increasing recalls, contamination events, and shortages, drug companies continue
to rely on outdated manufacturing plants and processes. Drug manufacturing's inefficiency …

Analysis of manufacturing costs in pharmaceutical companies

P Basu, G Joglekar, S Rai, P Suresh… - Journal of Pharmaceutical …, 2008 - Springer
In the pharmaceutical industry, costs attributed to manufacturing are a major part of a
company's total expenses. In this paper, trends in various expense and income categories of …

Manufacturing process innovation in the pharmaceutical industry

I Lugovoi, DA Andritsos… - Manufacturing & Service …, 2022 - pubsonline.informs.org
Problem definition: Process innovation is commonly claimed to be a major source of
competitive advantage for firms. Despite this perceived influence, it has received …

Evidence underlying policy proposals for sustainable anticancer drug prices: a systematic review

N Franzen, VP Retèl, W Schats, WH van Harten - JAMA oncology, 2020 - jamanetwork.com
Importance The financial consequences of high-expenditure innovative drugs and the
association of these consequences with access to cancer treatment are substantial. With …

Risk-based quality by design (QbD): A Taguchi perspective on the assessment of product quality, and the quantitative linkage of drug product parameters and clinical …

RP Cogdill, JK Drennen - Journal of Pharmaceutical Innovation, 2008 - Springer
For good reason, quality by design (QbD) has become a topic of significant interest within
the pharmaceutical industry. Whereas regulatory agencies and standard-setting …

Comprehensive taxonomy and worldwide trends in pharmaceutical policies in relation to country income status

N Maniadakis, G Kourlaba, J Shen, A Holtorf - BMC Health Services …, 2017 - Springer
Background Rapidly evolving socioeconomic and technological trends make it challenging
to improve access, effectiveness and efficiency in the use of pharmaceuticals. This paper …

Numerical simulations of contact drying in agitated filter-dryer

EK Sahni, B Chaudhuri - Chemical Engineering Science, 2013 - Elsevier
Continuum mechanics based computational methods were used to study the heat transfer
and particulate flow in an agitated filter-dryer. Numerical simulations of granular flow are …

Investigating mixing in a multi-dimensional rotary mixer: Experiments and simulations

SS Manickam, R Shah, J Tomei, TL Bergman… - Powder Technology, 2010 - Elsevier
Mixing is an important but poorly understood aspect in petrochemical, food, ceramics,
fertilizer and pharmaceutical processing and manufacturing. Segregation and mixing …