Hypertension is the leading risk factor for heart disease and stroke, and is estimated to
cause 9.4 million deaths globally every year. The pathogenesis of hypertension is complex …

Foetal development and infancy are life stages that are characterised by rapid growth,
development and maturation of organs and systems. Variation in the quality or quantity of …

It has long been understood that the pathogenesis of complex diseases such as diabetes
includes both genetic and environmental components. More recently, it has become clear …

BACKGROUND The concept of developmental programming suggests that the early life
environment influences offspring characteristics in later life, including the propensity to …

Though there are multiple routes through which parents can influence their offspring, recent
studies of environmentally induced epigenetic variation have highlighted the role of non …

Abundant evidence supports the association between low birth weight (LBW) and renal
dysfunction in humans. Anatomic measurements of infants, children, and adults show …

There is considerable evidence for induction of differential risk of noncommunicable
diseases in humans by variation in the quality of the early life environment. Studies in animal …

Thanks to remarkable advances in neonatal intensive care, infants who once had little
chance for survival can now enter adulthood. Yet the consequences of premature birth or …

Significance: Epidemiological and animal studies have demonstrated a close link between
maternal nutrition and chronic metabolic disease in children and adults. Compelling …

Metabolic syndrome is reaching epidemic proportions, particularly in developing countries.
In this review, we explore the concept—based on the developmental-origin-of-health-and …