Emerging trends in the field of inflammation and proteinopathy in ALS/FTD spectrum disorder

F De Marchi, T Franjkic, P Schito, T Russo, J Nimac… - Biomedicines, 2023 - mdpi.com
Proteinopathy and neuroinflammation are two main hallmarks of neurodegenerative
diseases. They also represent rare common events in an exceptionally broad landscape of …

[HTML][HTML] Pathological mechanisms of amyotrophic lateral sclerosis

Y Hu, W Chen, C Wei, S Jiang, S Li… - Neural Regeneration …, 2024 - journals.lww.com
Amyotrophic lateral sclerosis refers to a neurodegenerative disease involving the motor
system, the cause of which remains unexplained despite several years of research. Thus …

Novel gene–intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy

AN Cutrupi, RK Narayanan, G Perez-Siles, BR Grosz… - Brain, 2023 - academic.oup.com
Distal hereditary motor neuropathies (dHMNs) are a group of inherited diseases involving
the progressive, length-dependent axonal degeneration of the lower motor neurons. There …

Integrating transcriptomic and structural insights: revealing drug repurposing opportunities for sporadic ALS

N Sunildutt, F Ahmed, AR Chethikkattuveli Salih… - ACS …, 2024 - ACS Publications
Amyotrophic lateral sclerosis (ALS) is a progressive and devastating neurodegenerative
disorder characterized by the loss of upper and lower motor neurons, resulting in debilitating …

A Diagnostic Gene-Expression Signature in Fibroblasts of Amyotrophic Lateral Sclerosis

G Morello, V La Cognata, M Guarnaccia, V La Bella… - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease with
limited treatment options. Diagnosis can be difficult due to the heterogeneity and non …

[HTML][HTML] Tracing ALS Degeneration: Insights from Spinal Cord and Cortex Transcriptomes

NP Sneha, SAP Dharshini, Y Taguchi, MM Gromiha - Genes, 2024 - mdpi.com
Background/Objectives: Amyotrophic Lateral Sclerosis is a progressive neurodegenerative
disorder characterized by the loss of upper and lower motor neurons. Key factors …

Systematic Review and Meta-Analyses of Aminopeptidases as Prognostic Biomarkers in Amyotrophic Lateral Sclerosis

B Teruel-Peña, JL Gómez-Urquiza… - International Journal of …, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive loss of motor neurons in the spinal cord, brain stem, and cerebral cortex …

肌萎缩性脊髓侧索硬化的致病机制

Y Hu, W Chen, C Wei, S Jiang, S Li, X Wang… - 中国神经再生研究(英文 …, 2024 - sjzsyj.com.cn
肌萎缩脊髓侧索硬化是一种涉及运动系统的神经退行性疾病. 尽管经过多年的研究,
其病因仍未得到确切的解释, 了解和治疗该疾病的道路依然漫长. 就目前的研究表明 …

Proteomics Analysis of Lymphoblastoid Cell Lines from Patients with Amyotrophic Lateral Sclerosis

D Whitham, E Belenkiy, CC Darie, A Radu - Molecules, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) consists of the progressive degeneration of motor
neurons, caused by poorly understood mechanisms for which there is no cure. Some of the …

Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy: A new mechanism for motor neuron degeneration

AN Cutrupi, RK Narayanan, G Perez-Siles, BR Grosz… - bioRxiv, 2022 - biorxiv.org
Distal hereditary motor neuropathies (dHMNs) are a group of inherited diseases involving
the progressive, length-dependent axonal degeneration of the lower motor neurons. There …