The introduction of the in vitro evolution method known as SELEX (systematic evolution of
ligands by exponential enrichment) more than 30 years ago led to the conception of …

Targeted therapeutics underwent a revolution with the entry of monoclonal antibodies in the
medical toolkit. Oligonucleotide aptamers form another family of target agents that have …

Aptamers are high affinity single-stranded DNA/RNA molecules, produced by a
combinatorial procedure named SELEX (Systematic Evolution of Ligands by Exponential …

ABSTRACT Introduction: As 'chemical antibodies', aptamers have some advantages, such
as lack of immunogenicity, rapid tissue penetration, cell internalization and so on …

Aptamers are short single-strand oligonucleotides that can form secondary and tertiary
structures, fitting targets with high affinity and specificity. They are so-called “chemical …

Rapid and accurate diagnosis of various biomarkers associated with medical conditions
including early detection of viruses and bacteria with highly sensitive biosensors is currently …

The transcriptome and proteome encode distinct information that is important for
characterizing heterogeneous biological systems. We demonstrate a method to …

Aptamers are promising targeting agents for imaging and therapy of numerous diseases,
including cancer. However, a significant shortcoming of aptamers is their poor stability and …

The binding specificity and affinity of aptamers have long been harnessed as the key
elements in the development of aptamer‐based assays, particularly aptasensing …

Increased interest and insights gained by researchers on the roles of endothelial cells in the
pathophysiology of cancer, inflammatory, and cardiovascular diseases have led to the …