Photodynamic therapy—current limitations and novel approaches

G Gunaydin, ME Gedik, S Ayan - Frontiers in Chemistry, 2021 - frontiersin.org
Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via the
excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be …

[HTML][HTML] Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

R Alzeibak, TA Mishchenko, NY Shilyagina… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
The past decade has witnessed major breakthroughs in cancer immunotherapy. This
development has been largely motivated by cancer cell evasion of immunological control …

Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity

C Donohoe, MO Senge, LG Arnaut… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Photodynamic therapy is a promising approach for cancer treatment that relies on the
administration of a photosensitizer followed by tumor illumination. The generated oxidative …

Photodynamic therapy (PDT) of cancer: from local to systemic treatment

JM Dąbrowski, LG Arnaut - Photochemical & Photobiological Sciences, 2015 - pubs.rsc.org
Photodynamic therapy (PDT) requires a medical device, a photosensitizing drug and
adequate use of both to trigger biological mechanisms that can rapidly destroy the primary …

Endoplasmic reticulum-localized iridium (III) complexes as efficient photodynamic therapy agents via protein modifications

JS Nam, MG Kang, J Kang, SY Park… - Journal of the …, 2016 - ACS Publications
Protein inactivation by reactive oxygen species (ROS) such as singlet oxygen (1O2) and
superoxide radical (O2•–) is considered to trigger cell death pathways associated with …

[HTML][HTML] Photodynamic therapy (PDT): PDT mechanisms

RR Allison, K Moghissi - Clinical endoscopy, 2013 - synapse.koreamed.org
Photodynamic therapy (PDT) is a light based therapy used to ablate tumors. As practiced in
oncology a photosensitizing agent is applied and then activated by a specific wavelength …

Photodynamic therapy for cancer

DE Dolmans, D Fukumura, RK Jain - Nature reviews cancer, 2003 - nature.com
The therapeutic properties of light have been known for thousands of years, but it was only
in the last century that photodynamic therapy (PDT) was developed. At present, PDT is being …

Photodynamic therapy

TJ Dougherty, CJ Gomer, BW Henderson… - Journal of National …, 1998 - academic.oup.com
Photodynamic therapy involves administration of a tumorlocalizing photosensitizing agent,
which may require metabolic synthesis (ie, a prodrug), followed by activation of the agent by …

Photodynamic therapy and immunity: an update

R Falk‐Mahapatra, SO Gollnick - Photochemistry and …, 2020 - Wiley Online Library
Abstract Dr. Thomas Dougherty and his Oncology Foundation of Buffalo were the first to
support my (SOG) research into the effects of photodynamic therapy (PDT) on the host …

Photodynamic therapy and anti-tumour immunity

AP Castano, P Mroz, MR Hamblin - Nature Reviews Cancer, 2006 - nature.com
Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in
combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant …