Advances in stem cell research for the treatment of primary hypogonadism
L Li, V Papadopoulos - Nature Reviews Urology, 2021 - nature.com
In Leydig cell dysfunction, cells respond weakly to stimulation by pituitary luteinizing
hormone, and, therefore, produce less testosterone, leading to primary hypogonadism. The …
hormone, and, therefore, produce less testosterone, leading to primary hypogonadism. The …
Nitric oxide resistance in priapism associated with sickle cell disease: mechanisms, therapeutic challenges, and future directions
DA Pereira, FB Calmasini, FF Costa… - Journal of …, 2024 - jpet.aspetjournals.org
Patients with sickle cell disease (SCD) display priapism, a prolonged penile erection in the
absence of sexual arousal. The current pharmacological treatments for SCD-associated …
absence of sexual arousal. The current pharmacological treatments for SCD-associated …
Testosterone recovery therapy targeting dysfunctional Leydig cells
S Garza, V Papadopoulos - Andrology, 2023 - Wiley Online Library
Reduced serum testosterone affects millions of men across the world and has been linked to
several comorbidities, metabolic dysfunctions, and quality of life changes. The standard …
several comorbidities, metabolic dysfunctions, and quality of life changes. The standard …
Haptoglobin treatment contributes to regulating nitric oxide signal and reduces oxidative stress in the penis: A preventive treatment for priapism in sickle cell disease
PS Pereira, DA Pereira, FB Calmasini, LO Reis… - Frontiers in …, 2022 - frontiersin.org
Background: In sickle cell disease (SCD), reduced bioavailability of endothelial NO and
cGMP results in reduced expression of phosphodiesterase type 5 (PDE5), thus impairing the …
cGMP results in reduced expression of phosphodiesterase type 5 (PDE5), thus impairing the …
Testosterone deficiency in sickle cell disease: recognition and remediation
B Musicki, AL Burnett - Frontiers in Endocrinology, 2022 - frontiersin.org
Hypogonadism is common in men with sickle cell disease (SCD) with prevalence rates as
high as 25%. Testicular failure (primary hypogonadism) is established as the principal cause …
high as 25%. Testicular failure (primary hypogonadism) is established as the principal cause …
Hydroxyurea does not reverse functional alterations of the nitric oxide-cGMP pathway associated with priapism phenotype in corpus cavernosum from sickle cell …
DA Pereira, DA Pereira, P da Silva Pereira… - Plos one, 2023 - journals.plos.org
Sickle cell disease (SCD) is a genetic disorder that has been associated with priapism. The
role of hydroxyurea, a common SCD therapy, in influencing the nitric oxide (NO)-cGMP …
role of hydroxyurea, a common SCD therapy, in influencing the nitric oxide (NO)-cGMP …
Targeting heme in sickle cell disease: new perspectives on priapism treatment
THR Silveira, FB Calmasini, MG de Oliveira… - Frontiers in …, 2024 - frontiersin.org
Men with sickle cell disease (SCD) frequently experience priapism, defined as prolonged,
painful erections occurring without sexual arousal or desire. This urological emergency can …
painful erections occurring without sexual arousal or desire. This urological emergency can …
Intravascular hemolysis leads to exaggerated corpus cavernosum relaxation: Implication for priapism in sickle cell disease
APM Iacopucci, P da Silva Pereira… - The FASEB …, 2022 - Wiley Online Library
Patients with sickle cell disease (SCD) display priapism. Clinical studies have shown a
strong positive correlation between priapism and high levels of intravascular hemolysis in …
strong positive correlation between priapism and high levels of intravascular hemolysis in …
Resveratrol-nitric oxide donor hybrid effect on priapism in sickle cell and nitric oxide-deficient mouse
AK Pinheiro, DA Pereira, JL Dos Santos, FB Calmasini… - Plos one, 2022 - journals.plos.org
Background Children and adult with sickle cell disease (SCD) display priapism associated
with low nitric oxide (NO) bioavailability and oxidative stress in penis. Aim This study aimed …
with low nitric oxide (NO) bioavailability and oxidative stress in penis. Aim This study aimed …
Soluble guanylate cyclase stimulators and activators: new horizons in the treatment of priapism associated with sickle cell disease
DA Pereira, THR Silveira, FB Calmasini… - Frontiers in …, 2024 - frontiersin.org
Priapism, defined as a prolonged and often painful penile erection occurring without sexual
stimulation or desire, is a common complication in sickle cell disease (SCD), affecting up to …
stimulation or desire, is a common complication in sickle cell disease (SCD), affecting up to …