Radioiodinated metaiodobenzylguanidine: a review of its biodistribution and pharmacokinetics, drug interactions, cytotoxicity and dosimetry

AR Wafelman, CA Hoefnagel, RAA Maes… - European journal of …, 1994 - Springer
Since the introduction of radioiodinated metaiodobenzylguanidine in 1980, considerable
research has been performed, both in the chemical field and in medical sciences. However …

Radiolabeled metaiodobenzylguanidine for the treatment of neuroblastoma

SG DuBois, KK Matthay - Nuclear medicine and biology, 2008 - Elsevier
INTRODUCTION: Neuroblastoma is the most common pediatric extracranial solid cancer.
This tumor is characterized by metaiodobenzylguanidine (MIBG) avidity in 90% of cases …

131I-metaiodobenzylguanidine therapy of neuroblastoma and other neuroendocrine tumors

F Grünwald, S Ezziddin - Seminars in nuclear medicine, 2010 - Elsevier
Treatment with 131I-metaiodobenzylguanidine (MIBG) has been introduced to the
management of neuroendocrine tumors (NET) nearly 30 years ago. It provides efficient …

131I-metaiodobenzylguanidine (131I-MIBG) therapy for residual neuroblastoma: a mono-institutional experience with 43 patients

A Garaventa, O Bellagamba, MS Piccolo… - British journal of …, 1999 - nature.com
Incomplete response to therapy may compromise the outcome of children with advanced
neuroblastoma. In an attempt to improve tumour response we incorporated 131 I …

Treatment of neuroblastoma stage 4 with 131I-meta-iodo-benzylguanidine, high-dose chemotherapy and immunotherapy. A pilot study

T Klingebiel, P Bader, R Bares, J Beck, B Hero… - European Journal of …, 1998 - Elsevier
Disseminated neuroblastoma after infancy has a prognosis of approximately 10–20% with
conventional therapy. We investigated the role of high-dose chemotherapy (HDCT) with …

Is there a benefit of 131I-MIBG therapy in the treatment of children with stage 4 neuroblastoma?

M Schmidt, T Simon, B Hero, W Eschner… - Nuklearmedizin …, 2006 - thieme-connect.com
Aim: 131 I-meta-iodobenzylguanidine (131 I-MIBG) therapy has been used in
neuroblastoma treatment for many years but its value in high intensive first line treatment …

Metaiodobenzylguanidine (mIBG) in treatment of 47 patients with neuroblastoma: results of the German Neuroblastoma Trial

T Klingebiel, F Berthold, J Treuner… - Medical and …, 1991 - Wiley Online Library
Abstract From 1984 to 1989, 47 children with relapsed, refractory, and/or metastasized
neuroblastoma were treated with 131l‐metaiodobenzylguanidine (mlBG) in several different …

Dosimetry for 131I-MIBG therapies in metastatic neuroblastoma, phaeochromocytoma and paraganglioma

F Sudbrock, M Schmidt, T Simon, W Eschner… - European journal of …, 2010 - Springer
Purpose Radiation dosimetry is a basic requirement for targeted radionuclide therapies
(TRT) which have become of increasing interest in nuclear medicine. Despite the significant …

Pharmacokinetics and intracellular distribution of the tumor‐targeted radiopharmaceutical m‐iodo‐benzylguanidine in SK‐N‐SH neuroblastoma and PC‐12 …

LA Smets, M Janssen, M Rutgers… - … journal of cancer, 1991 - Wiley Online Library
Radioiodinated meta‐iodobenzylguanidine (MIBG) is increasingly used for the diagnosis
and targeted radiotherapy of neuro‐adrenergic tumors. We have investigated various …

Meta‐[211AT]astatobenzylguanidine: Further evaluation of a potential therapeutic agent

G Vaidyanathan, DK Strickland… - International journal of …, 1994 - Wiley Online Library
Abstract Meta‐[211At] astatobenzylguanidine ([211At] MABG) is an astatinated analogue of
meta‐iodobenzylguanidine (MIBG) that could be of value for therapeutic applications. The …