Ion channels and G protein–coupled receptors (GPCRs) are regulated by lipids in their
membrane environment. Structural studies combined with biophysical and molecular …

Ion channels play critical roles in cellular function by facilitating the flow of ions across the
membrane in response to chemical or mechanical stimuli. Ion channels operate in a lipid …

The regulation of ion channel activity by specific lipid molecules is widely recognized as an
integral component of electrical signalling in cells,. In particular, phosphatidylinositol 4, 5 …

Slo1 is a Ca2+-and voltage-activated K+ channel that underlies skeletal and smooth muscle
contraction, audition, hormone secretion and neurotransmitter release. In mammals, Slo1 is …

We present the first structure of the human Kir2. 1 channel containing both transmembrane
domain (TMD) and cytoplasmic domain (CTD). Kir2. 1 channels are strongly inward …

Protein–lipid interactions are a key element of the function of many integral membrane
proteins. These potential interactions should be considered alongside the complexity and …

The past decade, membrane signaling lipids emerged as major regulators of ion channel
function. However, the molecular nature of lipid binding to ion channels remained poorly …

Membrane proteins interact with a myriad of lipid species in the biological membrane,
leading to a bewildering number of possible protein− lipid assemblies. Despite this inherent …

Abstract Transient Receptor Potential (TRP) channels are activated by stimuli as diverse as
heat, cold, noxious chemicals, mechanical forces, hormones, neurotransmitters, spices, and …

Anionic phospholipids are minor but prominent components of the plasma membrane that
are necessary for ion channel function. Their persistence in bulk membranes, in particular …