DNA damage is the cause of numerous human pathologies including cancer, premature
aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn …

Malignant pleural mesothelioma (MPM) is a rare and fatal disease of the pleural lining. Up to
80% of the MPM cases are linked to asbestos exposure. Even though its use has been …

Reactive oxygen species damage DNA and result in health issues. The major damage
product, 8-oxo-7, 8-dihydroguanine (8oG), is repaired by human adenine DNA glycosylase …

Malignant mesothelioma (MMe) is an aggressive neoplasm that occurs through the
transformation of mesothelial cells. Asbestos exposure is the main risk factor for MMe …

In a thorough review of the literature, the complex roles of PRAME (preferentially expressed
Antigen of Melanoma) and BAP1 (BRCA1-associated protein 1) have been investigated in …

Ranked high in worldwide growing health issues, pleural diseases affect approximately one
million people globally per year and are often correlated with a poor prognosis. Among …

Diffuse malignant peritoneal mesothelioma (DMPM) prognosis was improved by the
locoregional treatment combining cytoreductive surgery (CRS) and hyperthermic …

Simple Summary A critical step in the success of immunotherapy is the presentation of tumor-
derived peptides by the major histocompatibility complex I (MHC-I) of tumor cells. These …

Simple Summary DNA repair has an important role in malignant pleural mesothelioma
tumorigenesis and progression. The prognosis of mesothelioma patients is very poor and …

Simple Summary Mesothelioma is a rare cancer arising from the mesothelium, the epithelial
lining of the pleura, peritoneum, pericardium and tunica vaginalis testis. Mesothelioma is a …