[HTML][HTML] Animal models of right heart failure
A Andersen, DE van der Feen, S Andersen… - Cardiovascular …, 2020 - ncbi.nlm.nih.gov
Right heart failure may be the ultimate cause of death in patients with acute or chronic
pulmonary hypertension (PH). As PH is often secondary to other cardiovascular diseases …
pulmonary hypertension (PH). As PH is often secondary to other cardiovascular diseases …
Current Overview of the Biology and Pharmacology in Sugen/Hypoxia-Induced Pulmonary Hypertension in Rats
MR Corboz, TL Nguyen, A Stautberg… - Journal of Aerosol …, 2024 - liebertpub.com
The Sugen 5416/hypoxia (Su/Hx) rat model of pulmonary arterial hypertension (PAH)
demonstrates most of the distinguishing features of PAH in humans, including increased …
demonstrates most of the distinguishing features of PAH in humans, including increased …
The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats
Y Honda, K Kosugi, C Fuchikami, K Kuramoto… - PLoS …, 2020 - journals.plos.org
Pulmonary arterial hypertension (PAH) is a lethal disease characterized by a progressive
increase in pulmonary artery pressure due to an increase in vessel tone and occlusion of …
increase in pulmonary artery pressure due to an increase in vessel tone and occlusion of …
Pulmonary arterial hypertension caused by AhR signal activation protecting against colitis
T Hiraide, T Teratani, S Uemura… - American journal of …, 2021 - atsjournals.org
Accumulating evidence indicates that AhR (aryl hydrocarbon receptor) ligands are crucial
mediators of host health and disease. The Chinese herbal medicine Qing-Dai contains high …
mediators of host health and disease. The Chinese herbal medicine Qing-Dai contains high …
Update in pulmonary vascular diseases and right ventricular dysfunction 2019
EA Goncharova, SY Chan, CE Ventetuolo… - American Journal of …, 2020 - atsjournals.org
The American Thoracic Society journals published numerous original research studies in
2019 that advance our understanding of the molecular pathogenesis of pulmonary vascular …
2019 that advance our understanding of the molecular pathogenesis of pulmonary vascular …
The adult sprague-dawley sugen-hypoxia rat is still “the One:” A model of group 1 pulmonary hypertension: Reply to le cras and abman
HJ Bogaard, E Legchenko, M Ackermann… - American journal of …, 2020 - atsjournals.org
Figure 1. Effects of neonatal SU5416 treatment on lung histology in infant and adult rats.
Lung histology of infant rats treated with a single dose of SU5416 on the first day of life …
Lung histology of infant rats treated with a single dose of SU5416 on the first day of life …
Early disruption of VEGF receptor signaling and the risk for adult Emphysema
TD Le Cras, SH Abman - … Journal of Respiratory and Critical Care …, 2020 - atsjournals.org
We read with interest two recent letters to the editor that describe the remarkable effects of
the combination of SU5416, an inhibitor of VEGFR2 signaling, with chronic hypoxia on …
the combination of SU5416, an inhibitor of VEGFR2 signaling, with chronic hypoxia on …
Experimental Models
M Boehm, RT Schermuly, B Kojonazarov - The Right Heart, 2021 - Springer
Animal models that mimic key features of the transition from right ventricular (RV) adaptation
towards decompensation and RV failure in the context of pulmonary hypertension are …
towards decompensation and RV failure in the context of pulmonary hypertension are …
[HTML][HTML] EFT-508 inhibitor
HJ Bogaard, MA de Raaf - eft-508inhibitor.com
We read with great interest the report by Chen et al. on a novel rat model of experimental
pulmonary hypertension (expPH) based on a single injection of SU5416 (Sugen-only) in …
pulmonary hypertension (expPH) based on a single injection of SU5416 (Sugen-only) in …