The protein family of facilitative glucose transporters comprises 14 isoforms that share
common structural features such as 12 transmembrane domains, N‐and C‐termini facing …

Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of
reliable animal models that mimic human disease has delayed the identification of specific …

Objective Development of these guidelines is mandated by the American Association of
Clinical Endocrinologists (AACE) Board of Directors and the American College of …

Diabetes is the leading cause of ESRD because diabetic nephropathy develops in 30 to
40% of patients. Diabetic nephropathy does not develop in the absence of hyperglycemia …

In the not-so-distant past, type 2 diabetes mellitus was thought to be a relatively benign
condition, at least in the elderly, with relatively little effect on life expectancy or renal function …

Diabetes mellitus contributes greatly to morbidity, mortality, and overall health care costs. In
major part, these outcomes derive from the high incidence of progressive kidney dysfunction …

Diabetes mellitus type 2 is a world-wide growing health problem affecting more than 150
million people at the beginning of the new millennium. It is believed that this number will …

Despite recent advances in the molecular genetics of type 2 diabetes, the majority of
susceptibility genes in humans remain to be identified. We therefore conducted a 10-cM …

To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes
susceptibility genes that increase the risk of type 2 diabetes (T2D) in a Han Chinese …

Type 2 diabetes is an increasingly common, serious metabolic disorder with a substantial
inherited component. It is characterised by defects in both insulin secretion and action …