Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …

This review focuses on a structure-based analysis of histone posttranslational modification
(PTM) readout, where the PTMs serve as docking sites for reader modules as part of larger …

Cultured meat is meat for consumption produced in a more sustainable way. It involves cell
harvesting and expansion, differentiation into myotubes, construction into muscle fibres and …

Eukaryotic cells activate the S-phase checkpoint in response to a variety of events affecting
the progression of replication forks, collectively referred to as replication stress. This …

The cellular response to DNA damage (DDR) that causes replication collapse and/or DNA
double strand breaks, is characterised by a massive change in the post-translational …

In response to genotoxic stress, a transient arrest in cell-cycle progression enforced by the
DNA-damage checkpoint (DDC) signalling pathway positively contributes to genome …

Abstract The multi-component Smc5/6 complex plays a critical role in the resolution of
recombination intermediates formed during mitosis and meiosis, and in the cellular …

The integrity of plant genetic information is constantly challenged by various internal and
external factors. Therefore, plants use a sophisticated molecular network to identify, signal …

DNA double-strand breaks (DSBs) are DNA lesions that must be accurately repaired in
order to preserve genomic integrity and cellular viability. The response to DSBs reshapes …

Checkpoints monitor critical cell cycle events such as chromosome duplication and
segregation. They are highly conserved mechanisms that prevent progression into the next …