Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

Highlights•Macrophages induce pain via pro-inflammatory cytokines that activate
nociceptors.•Nociceptor neurons activate local macrophages via TLR signaling and CCL2 …

Microglia, resident macrophages of the CNS, are essential to brain development,
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …

Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …

Relentless, repetitive itching and scratching is a debilitating feature of many chronic
inflammatory skin disorders such as atopic dermatitis. While well known clinically, this itch …

Although the medical definition of itch has been in existence for 360 years, only in the last 20
years have we begun to understand the basic mechanisms that underlie this unique …

Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …

The somatosensory system relays many signals ranging from light touch to pain and itch.
Touch is critical to spatial awareness and communication. However, in disease states …

Transient Receptor Potential (TRP) channels are multifunctional sensory molecules that are
abundant in the skin and are involved in the sensory pathways of itch, pain, and …

Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …