Runs of homozygosity: windows into population history and trait architecture
Long runs of homozygosity (ROH) arise when identical haplotypes are inherited from each
parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding …
parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding …
Genomics advances the study of inbreeding depression in the wild
Inbreeding depression (reduced fitness of individuals with related parents) has long been a
major focus of ecology, evolution, and conservation biology. Despite decades of research …
major focus of ecology, evolution, and conservation biology. Despite decades of research …
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …
Inbreeding and runs of homozygosity: A possible solution to an old problem
Quantifying human, plant and livestock inbreeding has been an important goal of
evolutionary biologists and agricultural scientists for nearly a century, and methods to do so …
evolutionary biologists and agricultural scientists for nearly a century, and methods to do so …
Complex disease and phenotype mapping in the domestic dog
JJ Hayward, MG Castelhano, KC Oliveira… - Nature …, 2016 - nature.com
The domestic dog is becoming an increasingly valuable model species in medical genetics,
showing particular promise to advance our understanding of cancer and orthopaedic …
showing particular promise to advance our understanding of cancer and orthopaedic …
Measuring individual inbreeding in the age of genomics: marker-based measures are better than pedigrees
Inbreeding (mating between relatives) can dramatically reduce the fitness of offspring by
causing parts of the genome to be identical by descent. Thus, measuring individual …
causing parts of the genome to be identical by descent. Thus, measuring individual …
Estimating the mutation load in human genomes
Next-generation sequencing technology has facilitated the discovery of millions of genetic
variants in human genomes. A sizeable fraction of these variants are predicted to be …
variants in human genomes. A sizeable fraction of these variants are predicted to be …
[图书][B] Human evolutionary genetics: origins, peoples and disease
M Jobling, C Tyler-Smith - 2019 - taylorfrancis.com
Human Evolutionary Genetics is a groundbreaking text which for the first time brings
together molecular genetics and genomics to the study of the origins and movements of …
together molecular genetics and genomics to the study of the origins and movements of …
Distance from sub-Saharan Africa predicts mutational load in diverse human genomes
The Out-of-Africa (OOA) dispersal∼ 50,000 y ago is characterized by a series of founder
events as modern humans expanded into multiple continents. Population genetics theory …
events as modern humans expanded into multiple continents. Population genetics theory …
Identification of genomic regions associated with inbreeding depression in Holstein and Jersey dairy cattle
Background Inbreeding reduces the fitness of individuals by increasing the frequency of
homozygous deleterious recessive alleles. Some insight into the genetic architecture of …
homozygous deleterious recessive alleles. Some insight into the genetic architecture of …