Neurodegenerative diseases (NDs) such as Alzheimer's Disease (AD) and Parkinson's
Disease (PD) are devastating conditions that can develop without noticeable symptoms …

Background The demand for high-quality systematic literature reviews (SRs) for evidence-
based medical decision-making is growing. SRs are costly and require the scarce resource …

Background: Depressive and manic episodes within bipolar disorder (BD) and major
depressive disorder (MDD) involve altered mood, sleep, and activity, alongside …

Abstract Background 'A Measurement Tool to Assess Systematic Reviews, version
2'(AMSTAR 2) is a validated 16-item scale designed to appraise systematic reviews (SRs) of …

Innovative Digital Medical Devices (DMDs) are gaining a growing importance in healthcare,
thus the interest regarding their actual clinical value is increasing. Gathering and evaluating …

Background: Clinical trials often use digital technologies to collect data continuously outside
the clinic and use the derived digital endpoints as trial endpoints. Digital endpoints are also …

Africa's dual burden of rising incidence of infectious diseases and increasing prevalence of
non-communicable diseases (NCDs), such as cardiovascular diseases and diabetes …

Hospital-at-home has been gaining increased attention as a potential remedy for the current
shortcomings of our health care system, allowing for essential health services to be provided …

Abstract Objectives We introduce the Bitemporal Lens Model, a comprehensive
methodology for chronic disease prevention using digital biomarkers. Materials and …

High-quality systematic reviews (SRs) can strengthen the evidence base for prevention and
health promotion. A 16-item AMSTAR 2 tool allows the appraisal of SRs by deriving a …