IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes ('psoriatic
disease') that is defined by shared molecular pathogenesis resulting in excessive …

The excellent clinical efficacy of anti-interleukin 17A (IL-17A) biologics on psoriasis indicates
a crucial pathogenic role of IL-17A in this autoinflammatory skin disease. IL-17A accelerates …

A key challenge in psoriasis therapy is the tendency for lesions to recur in previously
affected anatomical locations after treatment discontinuation following lesion resolution …

Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown
pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary …

Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

Interleukin-17A (IL-17A) is a pro-inflammatory cytokine with well-characterized biological
effects on stromal cell activation, angiogenesis, and osteoclastogenesis. The presence of …

Psoriatic arthritis (PsA) is a complex inflammatory disease with heterogeneous clinical
features, which complicates psoriasis in 30% of patients. There are no diagnostic criteria or …

Objective To compare immune cell phenotype and function in psoriatic arthritis (PsA) versus
psoriasis in order to better understand the pathogenesis of PsA. Methods In‐depth …

Summary CD69+ CD103+ tissue-resident memory T (T RM) cells are important drivers of
inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high …