Adipose tissue, diet and aging

M Zamboni, AP Rossi, F Fantin, G Zamboni… - Mechanisms of ageing …, 2014 - Elsevier
Age related increase in body fat mass, visceral adipose tissue (AT), and ectopic fat
deposition are strongly related to worse health conditions in the elderly. Moreover, with …

Cdc42: a novel regulator of insulin secretion and diabetes-associated diseases

QY Huang, XN Lai, XL Qian, LC Lv, J Li, J Duan… - International journal of …, 2019 - mdpi.com
Cdc42, a member of the Rho GTPases family, is involved in the regulation of several cellular
functions including cell cycle progression, survival, transcription, actin cytoskeleton …

Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI

EB Geer, W Shen, E Strohmayer… - The Journal of …, 2012 - academic.oup.com
Context: Cushing's Disease (CD) alters fat distribution, muscle mass, adipokine profile, and
cardiovascular risk factors. It is not known whether remission entirely reverses these …

Metabolic Implications of Dietary Trans‐fatty Acids

SE Dorfman, D Laurent, JS Gounarides, X Li… - …, 2009 - Wiley Online Library
Dietary trans‐fatty acids are associated with increased risk of cardiovascular disease and
have been implicated in the incidence of obesity and type 2 diabetes mellitus (T2DM). It is …

Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity

O Andersson, M Korach-Andre… - Proceedings of the …, 2008 - National Acad Sciences
Growth/differentiation factor 3 (GDF3) is highly expressed in adipose tissue, and previous
overexpression experiments in mice have suggested that it may act as an adipogenic factor …

Role of pregnane X receptor in obesity and glucose homeostasis in male mice

K Spruiell, RM Richardson, JM Cullen… - Journal of Biological …, 2014 - ASBMB
Clinical obesity is a complex metabolic disorder affecting one in three adults. Recent reports
suggest that pregnane X receptor (PXR), a xenobiotic nuclear receptor important for defense …

Effect of dexamethasone on glucose tolerance and fat metabolism in a diet-induced obesity mouse model

JS Gounarides, M Korach-Andre, K Killary… - …, 2008 - academic.oup.com
Prolonged exposure to elevated glucocorticoid levels is known to produce insulin resistance
(IR), a hallmark of diabetes mellitus. Although not fully elucidated, the underlying molecular …

[HTML][HTML] Glucocorticoids increase adipocytes in muscle by affecting IL-4 regulated FAP activity

Y Dong, KAS Silva, Y Dong, L Zhang - The FASEB Journal, 2014 - ncbi.nlm.nih.gov
An increase in intramuscular adipocyte tissue (IMAT) is associated with glucose
dysregulation, decreased muscle strength, and increased risk of disability. Unfortunately, the …

[HTML][HTML] Anti-atherosclerotic potential of aqueous extract of Cinnamomum zeylanicum bark against glucocorticoid induced atherosclerosis in wistar rats

IMN Nayak, R Chinta, R Jetti - Journal of clinical and diagnostic …, 2017 - ncbi.nlm.nih.gov
Aim To study the anti-atherosclerotic potential of C. zeylanicum bark extract in insulin
resistance associated atherosclerosis and worsened Atherogenic Index (AI) associated with …

Intramyocellular lipid is associated with visceral adiposity, markers of insulin resistance, and cardiovascular risk in prepubertal children: the EPOCH study

DE Brumbaugh, TL Crume, K Nadeau… - The Journal of …, 2012 - academic.oup.com
Context: The intramyocellular deposition of lipid associates with metabolic dysregulation in
adolescents and adults. Relatively little is known about the deposition of fat in muscle before …