Variation in expression of cytochrome P450 3A isoforms and toxicological effects: endo-and exogenous substances as regulatory factors and substrates
C Fujino, S Sanoh, T Katsura - Biological and Pharmaceutical …, 2021 - jstage.jst.go.jp
The CYP3A subfamily, which includes isoforms CYP3A4, CYP3A5, and CYP3A7 in humans,
plays important roles in the metabolism of various endogenous and exogenous substances …
plays important roles in the metabolism of various endogenous and exogenous substances …
Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif
The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and h CAIs) remain
key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity …
key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity …
Fluorescence-Based High-Throughput Assays for Investigating Cytochrome P450 Enzyme-Mediated Drug–Drug Interactions
R He, Z Dai, M Finel, F Zhang, D Tu, L Yang… - Drug Metabolism and …, 2023 - ASPET
The cytochrome P450 enzymes (CYPs), a group of heme-containing enzymes, catalyze
oxidative metabolism of a wide range of drugs and xenobiotics, as well as different …
oxidative metabolism of a wide range of drugs and xenobiotics, as well as different …
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin‐4(3H)‐one derivatives as potential aldose reductase inhibitors
A series of novel sulfonates containing quinazolin‐4 (3 H)‐one ring derivatives was
designed to inhibit aldose reductase (ALR2, EC 1.1. 1.21). Novel quinazolinone derivatives …
designed to inhibit aldose reductase (ALR2, EC 1.1. 1.21). Novel quinazolinone derivatives …
3D-QSAR study, docking molecular and simulation dynamic on series of benzimidazole derivatives as anti-cancer agents
L El Mchichi, K Tabti, R Kasmi, R El-Mernissi… - Journal of the Indian …, 2022 - Elsevier
Benzimidazole is an important heterocyclic organic compound which has a structural
analogy to nucleotides found in human body and hence is an important pharmacophore in …
analogy to nucleotides found in human body and hence is an important pharmacophore in …
A molecular dynamics simulation study of the ACE2 receptor with screened natural inhibitors to identify novel drug candidate against COVID-19
Methods In the present study, the human angiotensin-converting enzyme 2 (ACE2) receptor
was the target for the designing of drugs against the deadly virus. The 3D structure of the …
was the target for the designing of drugs against the deadly virus. The 3D structure of the …
QSAR and molecular docking studies of pyrimidine-coumarin-triazole conjugates as prospective anti-breast cancer agents
AK Subramani, A Sivaperuman, R Natarajan… - Molecules, 2022 - mdpi.com
Cancer is a life-threatening disease and is the second leading cause of death worldwide.
Although many drugs are available for the treatment of cancer, survival outcomes are very …
Although many drugs are available for the treatment of cancer, survival outcomes are very …
Identification of SARS‐CoV‐2 Main Protease Inhibitors Using Structure Based Virtual Screening and Molecular Dynamics Simulation of DrugBank Database
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) is highly
pathogenic to humans and has created an unprecedented global health care threat …
pathogenic to humans and has created an unprecedented global health care threat …
Unraveling the structural basis of selective inhibition of human cytochrome P450 3A5
J Wang, CD Buchman, J Seetharaman… - Journal of the …, 2021 - ACS Publications
The human cytochrome P450 (CYP) CYP3A4 and CYP3A5 enzymes metabolize more than
one-half of marketed drugs. They share high structural and substrate similarity and are often …
one-half of marketed drugs. They share high structural and substrate similarity and are often …
Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease
KA Lidberg, AJ Annalora, M Jozic, DJ Elson, L Wang… - Scientific reports, 2021 - nature.com
CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its
aberrant expression may contribute to a broad spectrum of renal disorders …
aberrant expression may contribute to a broad spectrum of renal disorders …