Immunometabolism: cellular metabolism turns immune regulator

RM Loftus, DK Finlay - Journal of Biological Chemistry, 2016 - ASBMB
Immune cells are highly dynamic in terms of their growth, proliferation, and effector functions
as they respond to immunological challenges. Different immune cells can adopt distinct …

Multifaceted roles of glycolytic enzymes

J Kim, CV Dang - Trends in biochemical sciences, 2005 - cell.com
Although glycolysis is a biochemical pathway that evolved under ancient anaerobic
terrestrial conditions, recent studies have provided evidence that some glycolytic enzymes …

New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase

MA Sirover - Biochimica et Biophysica Acta (BBA)-Protein Structure …, 1999 - Elsevier
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was considered a classical
glycolytic protein examined for its pivotal role in energy production. It was also used as a …

GAPDH: a common enzyme with uncommon functions

C Nicholls, H Li, JP Liu - Clinical and Experimental …, 2012 - Wiley Online Library
Glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) has long been recognized as an
important enzyme for energy metabolism and the production of ATP and pyruvate through …

Glucose, glycolysis and lymphocyte responses

RP Donnelly, DK Finlay - Molecular immunology, 2015 - Elsevier
Activated lymphocytes engage in robust growth and rapid proliferation. To achieve this, they
tend to adopt a form of glucose metabolism termed aerobic glycolysis. This type of …

Cellular proteins in influenza virus particles

ML Shaw, KL Stone, CM Colangelo, EE Gulcicek… - PLoS …, 2008 - journals.plos.org
Virions are thought to contain all the essential proteins that govern virus egress from the host
cell and initiation of replication in the target cell. It has been known for some time that …

Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration

DA Butterfield, SS Hardas… - Journal of Alzheimer's …, 2010 - content.iospress.com
Abstract Recently, the oxidoreductase, glyceraldehyde-3-phosphate dehydrogenase
(GAPDH), has become a subject of interest as more and more studies reveal a surfeit of …

The La and related RNA‐binding proteins (LARPs): structures, functions, and evolving perspectives

RJ Maraia, S Mattijssen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
La was first identified as a polypeptide component of ribonucleic protein complexes targeted
by antibodies in autoimmune patients and is now known to be a eukaryote cell‐ubiquitous …

Biological targets for isatin and its analogues: Implications for therapy

A Medvedev, O Buneeva, V Glover - Biologics: Targets and …, 2007 - Taylor & Francis
Isatin and its metabolites are constituents of many natural substances. They are also
components of many synthetic compounds exhibiting a wide range of effects, including …

Cellular factors in the transcription and replication of viral RNA genomes: a parallel to DNA-dependent RNA transcription

MMC Lai - Virology, 1998 - Elsevier
Viral RNA replication and transcription involves not only viral RNA-dependent RNA
polymerases, but also cellular proteins, the majority of which are subverted from the RNA …