Understanding acquired brain injury: a review

L Goldman, EM Siddiqui, A Khan, S Jahan… - Biomedicines, 2022 - mdpi.com
Any type of brain injury that transpires post-birth is referred to as Acquired Brain Injury (ABI).
In general, ABI does not result from congenital disorders, degenerative diseases, or by brain …

MicroRNA-based therapeutics in central nervous system injuries

P Sun, DZ Liu, GC Jickling… - Journal of Cerebral …, 2018 - journals.sagepub.com
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …

Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions

BL Edlow, LRD Sanz, L Polizzotto, N Pouratian… - Neurocritical care, 2021 - Springer
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

[HTML][HTML] A review of the pathology and treatment of TBI and PTSD

M Monsour, D Ebedes, CV Borlongan - Experimental neurology, 2022 - Elsevier
This literature review focuses on the underlying pathophysiology of TBI and PTSD
symptoms, while also examining the plethora of stem cell treatment options to ameliorate …

Immune modulation after traumatic brain injury

M Bouras, K Asehnoune, A Roquilly - Frontiers in Medicine, 2022 - frontiersin.org
Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue,
followed by a systematization of the inflammatory response. The subsequent response …

Cell therapy for chronic TBI: interim analysis of the randomized controlled STEMTRA trial

M Kawabori, AH Weintraub, H Imai, I Zinkevych… - Neurology, 2021 - AAN Enterprises
Objective To determine whether chronic motor deficits secondary to traumatic brain injury
(TBI) can be improved by implantation of allogeneic modified bone marrow–derived …

[HTML][HTML] Bioorthogonal DOPA-NGF activated tissue engineering microunits for recovery from traumatic brain injury by microenvironment regulation

W Zhu, L Chen, Z Wu, W Li, X Liu, Y Wang, M Guo… - Acta Biomaterialia, 2022 - Elsevier
Stem cell treatment is vital for recovery from traumatic brain injury (TBI). However, severe TBI
usually leads to excessive inflammation and neuroinhibitory factors in the injured brain …

Cell-based therapies for neurological disorders—the bioreactor hypothesis

SI Savitz, CS Cox Jr - Nature Reviews Neurology, 2023 - nature.com
Cell-based therapies are an emerging biopharmaceutical paradigm under investigation for
the treatment of a range of neurological disorders. Accumulating evidence is demonstrating …

Therapeutic applications of stem cells and extracellular vesicles in emergency care: futuristic perspectives

S Öztürk, AE Elçin, A Koca, YM Elçin - Stem Cell Reviews and Reports, 2021 - Springer
Regenerative medicine (RM) is an interdisciplinary field that aims to repair, replace or
regenerate damaged or missing tissue or organs to function as close as possible to its …

Neuroprotection in traumatic brain injury

KK Jain, KK Jain - The handbook of neuroprotection, 2019 - Springer
Neuroprotection is important in injuries of the CNS. Immediate damage from the injury may
not be reversible but the progression of the chain of events, which aggravate brain damage …