The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …

Animals rely on their nervous systems to process sensory inputs, integrate these with
internal signals, and produce behavioral outputs. This is enabled by the highly specialized …

The regulation of gliogenesis is a fundamental process for nervous system development, as
the appropriate glial number and identity is required for a functional nervous system. To …

Cells of the same type can be generated by distinct cellular lineages that originate in
different parts of the developing embryo ('lineage convergence'). Several Caenorhabditis …

During convergent differentiation, multiple developmental lineages produce a highly similar
or identical cell type. However, few molecular players that drive convergent differentiation …

Animals use behavioral strategies to seek optimal environments. Population behavioral
assays provide a robust means to determine the effect of genetic perturbations on the ability …

Glia make up roughly half of all cells in the mammalian nervous system and play a major
part in nervous system development, function and disease. Although research in the past …

Classic cell lineage studies in the nematode Caenorhabditis elegans as well as recent
lineage tracing in vertebrates have shown that cells of the same type can be generated by …

Aging can be defined as time-dependent decline in organ functions concomitant with an
increase in probability of death, and it begins after the organism has achieved its maximum …