5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …

In the last few years, there has been a wave of articles related to behavioral addictions;
some of them have a focus on online pornography addiction. However, despite all efforts, we …

Rhythmic gene expression is found throughout the central nervous system. This harmonized
regulation can be dependent on-and independent of-the master regulator of biological …

Abstract The Research Domain Criteria (RDoC) and the Hierarchical Taxonomy of
Psychopathology (HiTOP) represent major dimensional frameworks proposing two …

The literature on affective determinants of physical activity (PA) is growing rapidly. The
present paper aims to provide greater clarity regarding the definition and distinctions among …

Addiction, the most severe form of substance use disorder, is a chronic brain disorder
molded by strong biosocial factors that has devastating consequences to individuals and to …

Alexithymia is a sub-clinical construct, traditionally characterized by difficulties identifying
and describing one's own emotions. Despite the clear need for interoception (interpreting …

Nonmedical prescription opioid misuse remains a growing public problem in need of action
and is concentrated in areas of US states with large rural populations such as Kentucky …

Dopamine is well recognized as a neurotransmitter in the brain, and regulates critical
functions in a variety of peripheral systems. Growing research has also shown that …