Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Mechanisms of mesenchymal stem/stromal cell function

JL Spees, RH Lee, CA Gregory - Stem cell research & therapy, 2016 - Springer
The past decade has seen an explosion of research directed toward better understanding of
the mechanisms of mesenchymal stem/stromal cell (MSC) function during rescue and repair …

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

X Wang, HH Gerdes - Cell Death & Differentiation, 2015 - nature.com
Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in
culture and in tissues. They mediate intercellular communication ranging from electrical …

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

M Tardivel, S Bégard, L Bousset, S Dujardin… - Acta neuropathologica …, 2016 - Springer
A given cell makes exchanges with its neighbors through a variety of means ranging from
diffusible factors to vesicles. Cells use also tunneling nanotubes (TNTs), filamentous-actin …

Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes

S Abounit, L Bousset, F Loria, S Zhu… - The EMBO …, 2016 - embopress.org
Synucleinopathies such as Parkinson's disease are characterized by the pathological
deposition of misfolded α‐synuclein aggregates into inclusions throughout the central and …

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

J Pasquier, BS Guerrouahen, H Al Thawadi… - Journal of translational …, 2013 - Springer
Our vision of cancer has changed during the past decades. Indeed tumors are now
perceived as complex entities where tumoral and stromal components interact closely …

Tunneling nanotubes and gap junctions–their role in long-range intercellular communication during development, health, and disease conditions

J Ariazi, A Benowitz, V De Biasi… - Frontiers in molecular …, 2017 - frontiersin.org
Cell-to-cell communication is essential for the organization, coordination, and development
of cellular networks and multi-cellular systems. Intercellular communication is mediated by …

Peering into tunneling nanotubes—The path forward

D Cordero Cervantes, C Zurzolo - The EMBO journal, 2021 - embopress.org
Abstract The identification of Tunneling Nanotubes (TNTs) and TNT‐like structures signified
a critical turning point in the field of cell‐cell communication. With hypothesized roles in …

Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma

E Lou, S Fujisawa, A Morozov, A Barlas, Y Romin… - PloS one, 2012 - journals.plos.org
Tunneling nanotubes are long, non-adherent F-actin-based cytoplasmic extensions which
connect proximal or distant cells and facilitate intercellular transfer. The identification of …

Inter and Intracellular mitochondrial trafficking in health and disease

S Shanmughapriya, D Langford… - Ageing research …, 2020 - Elsevier
Neurons and glia maintain central nervous system (CNS) homeostasis through diverse
mechanisms of intra-and intercellular signaling. Some of these interactions include the …