Cell biology and pathology of podocytes
A Greka, P Mundel - Annual review of physiology, 2012 - annualreviews.org
As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a
unique geographical position: It is exposed to chemical signals from the urinary space …
unique geographical position: It is exposed to chemical signals from the urinary space …
Ion channels and channelopathies in glomeruli
A Staruschenko, R Ma, O Palygin… - Physiological …, 2023 - journals.physiology.org
An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin
RX Wang, JS Lee, EL Campbell… - Proceedings of the …, 2020 - National Acad Sciences
The intestinal mucosa exists in dynamic balance with trillions of luminal microbes. Disruption
of the intestinal epithelial barrier, commonly observed in mucosal inflammation and …
of the intestinal epithelial barrier, commonly observed in mucosal inflammation and …
[HTML][HTML] Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy
G Haddad, JM Lorenzen, H Ma… - The Journal of …, 2021 - Am Soc Clin Investig
Primary membranous nephropathy (pMN) is a leading cause of nephrotic syndrome in
adults. In most cases, this autoimmune kidney disease is associated with autoantibodies …
adults. In most cases, this autoimmune kidney disease is associated with autoantibodies …
[HTML][HTML] Regulation of the actin cytoskeleton in podocytes
J Blaine, J Dylewski - Cells, 2020 - mdpi.com
Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …
filtration of large proteins and macromolecules into the urine. Podocyte function is …
The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
The immunosuppressive action of the calcineurin inhibitor cyclosporine A (CsA) stems from
the inhibition of nuclear factor of activated T cells (NFAT) signaling in T cells. CsA is also …
the inhibition of nuclear factor of activated T cells (NFAT) signaling in T cells. CsA is also …
[HTML][HTML] The podocyte's response to injury: role in proteinuria and glomerulosclerosis
SJ Shankland - Kidney international, 2006 - Elsevier
The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are
highly specialized cells. They function as a critical size and charge barrier to prevent …
highly specialized cells. They function as a critical size and charge barrier to prevent …
[HTML][HTML] COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
SF Heeringa, G Chernin, M Chaki… - The Journal of …, 2011 - Am Soc Clin Investig
Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of end-stage renal failure.
Identification of single-gene causes of SRNS has generated some insights into its …
Identification of single-gene causes of SRNS has generated some insights into its …
Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton
C Faul, K Asanuma, E Yanagida-Asanuma, K Kim… - Trends in cell …, 2007 - cell.com
Podocytes of the renal glomerulus are unique cells with a complex cellular organization
consisting of a cell body, major processes and foot processes. Podocyte foot processes form …
consisting of a cell body, major processes and foot processes. Podocyte foot processes form …