Diabetes or diabetes mellitus is a complex or polygenic disorder, which is characterized by
increased levels of glucose (hyperglycemia) and deficiency in insulin secretion or resistance …

Background: Thiazolidine-2, 4-dione (2, 4-TZD) is a flexible pharmacophore and a
privileged platform and contains a five-membered ring with a 2-oxygen atom with double …

Coumarins are plant-derived natural products with a broad range of known pharmacological
activities including anticancer effects. However, the molecular mechanisms by which this …

Salts of weakly basic drugs can partially dissociate in formulations, to give basic drugs and
counter acids. The aim of the present study was to clarify the effect of physicochemical …

Human immunodeficiency virus type 1 integrase is one of the most attractive targets for the
development of anti-HIV-1 inhibitors. The capacity of a series of 2, 1, 3-benzoxadiazoles …

Diabetes mellitus is a chronic metabolic disorder marked by persistently elevated blood
sugar levels. left untreated over a long duration can cause multiple body disorders and may …

The review discusses the literature data on the structures of hypoglycemic compounds with
different mechanisms of action. It is shown that many drugs acting on different biological …

Réduire l'utilisation des produits phytosanitaires, sans affecter le rendement et la qualité des
productions agricoles, est l'un des grands enjeux du XXIe siècle. La recherche de nouvelles …

DESIGN, SYNTHESIS, BIOLOGICAL EVALUATION AND IN SILICO STUDIES OF SOME NOVEL
3-SUBSTITUTED- 5-([1,1'-BIPHENYL]-4- YL METHYLENE) Page 1 DESIGN, SYNTHESIS …

Интеграза вируса иммунодефицита человека типа 1 (ВИЧ-1) считается одной из самых
привлекательных мишеней для разработки ингибиторов этого вируса. В настоящей …