Nanomedicines improve drug bioavailability, the dose–response relationship, targeting
ability, efficacy and safety compared to conventional freely administered drugs …

Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important
component of the extracellular matrix. This leads to the remodelling of the extracellular …

Hyperspectral imaging (HSI) and multispectral imaging (MSI) technologies have the
potential to transform the fields of digital and computational pathology. Traditional digitized …

Pericytes are a heterogeneous population of cells located in the blood vessel wall. They
were first identified in the 19th century by Rouget, however their biological role and potential …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

Pericytes are multipotent perivascular cells whose involvement in vasculature development
is well established. Evidences in the literature also suggest that pericytes display immune …

Recent developments in nanotechnology have brought new approaches to cancer
diagnosis and therapy. While enhanced permeability and retention effect (EPR) promotes …

Although renal cell carcinoma is one of several tumor types responsive to immune
checkpoint inhibitors, the effectiveness of these agents is likely to be limited by the various …

Despite all efforts made to develop predictive biomarkers for antiangiogenic therapies, no
unambiguous markers have been identified so far. This is due to among others the lack of …

The field of anatomic pathology has changed significantly over the last decades and, as a
result of the technological developments in molecular pathology and genetics, has had …