The outer membrane protects Gram‐negative bacteria against a harsh environment. At the
same time, the embedded proteins fulfil a number of tasks that are crucial to the bacterial …

The unifying feature of all proteins that are transported out of the cytoplasm of gram-negative
bacteria by the general secretory pathway (GSP) is the presence of a long stretch of …

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Practically any oligopeptide can be exposed on the surface of the bacteriophage capsid by
fusion to the major coat protein of filamentous bacteriophages. A phage expressing a …

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Display of heterologous proteins on the surface of microorganisms, enabled by means of
recombinant DNA technology, has become an increasingly used strategy in various …

The outer membrane of Gram-negative bacteria presents an effective barrier that restricts the
release of proteins from the cell. Virtually all extracellular proteins of Gram-negative bacteria …

The first scientific attempts to control an infectious disease can be attributed to Edward
Jenner, who, in 1796 inoculated an 8-year-old boy with cowpox (vaccinia), giving the boy …

Following the discovery in the late 1960s of the tools for manipulating DNA sequences in
vitro, the expression of genes in Escherichia coli has become established as a key …

For the design of potent subunit vaccines, it is of paramount importance to identify all
antigens immunologically recognized by a patient population infected with a pathogen. We …