Non-small-cell lung cancer is one of the leading causes of deaths from cancer worldwide.
Therefore, improvements in diagnostics and treatments are urgently needed. In this review …

The liver displays an outstanding wound healing and regenerative capacity unmatched by
any other organ. This reparative response is governed by a complex network of …

Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase
MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and …

Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in
tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and …

Context Leucovorin, fluorouracil, and oxaliplatin (FOLFOX) is the standard adjuvant therapy
for resected stage III colon cancer. Adding cetuximab to FOLFOX benefits patients with …

Chemotherapy and molecularly targeted approaches represent two very different modes of
cancer treatment and each is associated with unique benefits and limitations. Both types of …

Predictive markers are factors that are associated with upfront response or resistance to a
particular therapy. Predictive markers are important in oncology as tumors of the same tissue …

Kinase inhibitors such as imatinib have dramatically improved outcomes for patients with
gastrointestinal stromal tumor (GIST), but many patients develop resistance to these …

Activation of hypoxia-inducible factor 1 (HIF-1) signaling is observed in a broad range of
human cancers due to tumor hypoxia and epigenetic mechanisms. HIF-1 activation leads to …

Background Glioblastoma (GBM) is the most lethal and common type of primary brain tumor.
Recent evidence suggests that a subpopulation of GBM cells (glioblastoma stem cells …