[HTML][HTML] Targeting signaling pathways in prostate cancer: mechanisms and clinical trials

Y He, W Xu, YT Xiao, H Huang, D Gu… - Signal transduction and …, 2022 - nature.com
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

The interactions of docetaxel with tumor microenvironment

R Gupta, MM Kadhim, AT Jalil, MQ Alasheqi… - International …, 2023 - Elsevier
There are several interactions within the tumor microenvironment (TME) that affect the
response of cancer cells to therapy. There are also a large number of cells and secretions in …

[HTML][HTML] Future regenerative medicine developments and their therapeutic applications

AE Altyar, A El-Sayed, A Abdeen, M Piscopo… - Biomedicine & …, 2023 - Elsevier
Although the currently available pharmacological assays can cure most pathological
disorders, they have limited therapeutic value in relieving certain disorders like myocardial …

[HTML][HTML] Stromal cells in prostate cancer pathobiology: friends or foes?

F Pederzoli, M Raffo, H Pakula, F Ravera… - British Journal of …, 2023 - nature.com
The genomic, epigenetic and metabolic determinants of prostate cancer pathobiology have
been extensively studied in epithelial cancer cells. However, malignant cells constantly …

[HTML][HTML] Emerging role of IGF-1 in prostate cancer: a promising biomarker and therapeutic target

G Liu, M Zhu, M Zhang, F Pan - Cancers, 2023 - mdpi.com
Simple Summary Prostate cancer (PCa) affects millions of men globally, and approximately
20% of PCa patients are found after they develop into a lethal metastatic or castration …

Computational drug discovery for castration-resistant prostate cancers through in vitro drug response modeling

W Zhang, AM Lee, S Jena, Y Huang… - Proceedings of the …, 2023 - National Acad Sciences
Prostate cancer (PC) is the most frequently diagnosed malignancy and a leading cause of
cancer deaths in US men. Many PC cases metastasize and develop resistance to systemic …

[HTML][HTML] Role of bFGF in acquired resistance upon anti-VEGF therapy in cancer

FT Zahra, MS Sajib, CM Mikelis - Cancers, 2021 - mdpi.com
Simple Summary Anti-angiogenic therapies targeting the vascular endothelial growth factor
(VEGF) signaling are established in the arsenal of cancer treatments. Despite the …

[HTML][HTML] Angioprevention of urologic cancers by plant-derived foods

M García-Caballero, JA Torres-Vargas, AD Marrero… - Pharmaceutics, 2022 - mdpi.com
The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable
advances achieved by basic research and clinical practice. Urologic tumors, including some …

[HTML][HTML] Advances in landscape and related therapeutic targets of the prostate tumor microenvironment: Therapeutic targets of the prostate tumor microenvironment

D Li, W Xu, Y Chang, Y Xiao, Y He… - Acta Biochimica et …, 2023 - ncbi.nlm.nih.gov
The distinct tumor microenvironment (TME) of prostate cancer (PCa), which promotes tumor
proliferation and progression, consists of various stromal cells, immune cells, and a dense …

[HTML][HTML] Three-dimensional growth of prostate cancer cells exposed to simulated microgravity

D Dietrichs, D Grimm, J Sahana, D Melnik… - Frontiers in Cell and …, 2022 - frontiersin.org
Prostate cancer metastasis has an enormous impact on the mortality of cancer patients.
Factors involved in cancer progression and metastasis are known to be key players in …