Pine wilt disease (PWD) is perhaps the most serious threat to pine forests worldwide. The
causative agent of PWD, the pinewood nematode (PWN), engages in a symbiotic …

Nematodes are presumably the most abundant Metazoa on Earth, and can even be found in
some of the most hostile environments of our planet. Various types of hypobiosis evolved to …

Small-molecule ligands of nuclear hormone receptors (NHRs) govern the transcriptional
regulation of metazoan development, cell differentiation, and metabolism. However, the …

The pinewood nematode Bursaphelenchus xylophilus has caused severe damage to pine
forests in large parts of the world [1–4]. Dispersal of this plant-parasitic nematode occurs …

Parasitic helminths secrete and excrete a vast array of molecules known to help skew or
suppress the host's immune response, thereby establishing a niche for sustained parasite …

Here, we discovered an endogenous dafachronic acid (DA) in the socioeconomically
important parasitic nematode Haemonchus contortus. We demonstrate that DA promotes …

The existence of small-molecule signals that influence development in Caenorhabditis
elegans has been known for several decades, but only in recent years have the chemical …

The complex life cycle of the parasitic nematode Strongyloides stercoralis leads to either
developmental arrest of infectious third-stage larvae (iL3) or growth to reproductive adults. In …

The native particulate guanylyl cyclase B receptor (pGC-B) activator, C-type natriuretic
peptide (CNP), induces anti-remodeling actions in the heart and kidney through the …

Cafestol, a coffee diterpene, is a known agonist of farnesoid X receptors (FXR), which are
involved in cholesterol homeostasis. FXR plays critical roles in other lipid metabolic …