Targeting neuraminidase: the next frontier for broadly protective influenza vaccines
NC Wu, AH Ellebedy - Trends in Immunology, 2023 - cell.com
Current seasonal influenza vaccines, which mainly target hemagglutinin (HA), require
annual updates due to the continuous antigenic drift of the influenza virus. Developing an …
annual updates due to the continuous antigenic drift of the influenza virus. Developing an …
[HTML][HTML] Avian influenza a (H5N1) neuraminidase inhibition antibodies in healthy adults after exposure to influenza a (H1N1) pdm09
P Daulagala, SMS Cheng, A Chin… - Emerging Infectious …, 2024 - ncbi.nlm.nih.gov
We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A
(H5N1) virus clade 2.3. 4.4 b in 96.8%(61/63) of serum samples from healthy adults in Hong …
(H5N1) virus clade 2.3. 4.4 b in 96.8%(61/63) of serum samples from healthy adults in Hong …
Drift and shape—new insights into human immunity against influenza virus neuraminidase
A Fox - Mbio, 2023 - Am Soc Microbiol
Influenza virus hemagglutinin mediates infection by binding sialic acids, whereas
neuraminidase cleaves sialic acids to release progeny virions. Both are targets of protective …
neuraminidase cleaves sialic acids to release progeny virions. Both are targets of protective …
[HTML][HTML] Capsid virus-like particle display improves recombinant influenza neuraminidase antigen stability and immunogenicity in mice
H Kang, MR Martinez, KL Aves, AK Okholm, H Wan… - iScience, 2024 - cell.com
Supplementing influenza vaccines with additional protective antigens such as
neuraminidase (NA) is a promising strategy for increasing the breadth of the immune …
neuraminidase (NA) is a promising strategy for increasing the breadth of the immune …
[HTML][HTML] Reconstructed influenza A/H3N2 infection histories reveal variation in incidence and antibody dynamics over the life course
Humans experience many influenza infections over their lives, resulting in complex and
varied immunological histories. Although experimental and quantitative analyses have …
varied immunological histories. Although experimental and quantitative analyses have …