Targeting neuraminidase: the next frontier for broadly protective influenza vaccines

NC Wu, AH Ellebedy - Trends in Immunology, 2023 - cell.com
Current seasonal influenza vaccines, which mainly target hemagglutinin (HA), require
annual updates due to the continuous antigenic drift of the influenza virus. Developing an …

[HTML][HTML] Avian influenza a (H5N1) neuraminidase inhibition antibodies in healthy adults after exposure to influenza a (H1N1) pdm09

P Daulagala, SMS Cheng, A Chin… - Emerging Infectious …, 2024 - ncbi.nlm.nih.gov
We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A
(H5N1) virus clade 2.3. 4.4 b in 96.8%(61/63) of serum samples from healthy adults in Hong …

Drift and shape—new insights into human immunity against influenza virus neuraminidase

A Fox - Mbio, 2023 - Am Soc Microbiol
Influenza virus hemagglutinin mediates infection by binding sialic acids, whereas
neuraminidase cleaves sialic acids to release progeny virions. Both are targets of protective …

[HTML][HTML] Capsid virus-like particle display improves recombinant influenza neuraminidase antigen stability and immunogenicity in mice

H Kang, MR Martinez, KL Aves, AK Okholm, H Wan… - iScience, 2024 - cell.com
Supplementing influenza vaccines with additional protective antigens such as
neuraminidase (NA) is a promising strategy for increasing the breadth of the immune …

[HTML][HTML] Reconstructed influenza A/H3N2 infection histories reveal variation in incidence and antibody dynamics over the life course

JA Hay, H Zhu, CQ Jiang, KO Kwok, R Shen… - medRxiv, 2024 - ncbi.nlm.nih.gov
Humans experience many influenza infections over their lives, resulting in complex and
varied immunological histories. Although experimental and quantitative analyses have …