Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …

Osteopontin (OPN) is a multifunctional protein, initially identified in osteosarcoma cells with
its role of mediating osteoblast adhesion. Later studies revealed that OPN is associated with …

CXCL8 (also known as IL‐8) can produce different biological effects by binding to its
receptors: CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC). CXCL8 …

Improved outcomes for many types of cancer achieved during recent years is due, among
other factors, to the earlier detection of tumours and the greater availability of screening …

Classically, osteopontin (OPN) has been described as a secreted glycophosprotein. Indeed,
most data concerning its physiological and pathological roles are mainly related to the …

Introduction Increasing evidence suggests that it is necessary to find effective and robust
clinically validated prognostic biomarkers that can identify “high-risk” colorectal cancer …

Osteopontin (OPN) is a multifunctional phosphorylated glycoprotein that is expressed at
significantly elevated levels in various cancers. OPN overexpression is closely associated …

Objective To explore the expression of secreted phosphoprotein 1 (SPP1) in lung
adenocarcinoma (LUAD), and evaluate its relationship with clinicopathological …

Background. Non-small cell lung cancer (NSCLC) is the most prevalent malignant tumor of
the lung cancer, for which the molecular mechanisms remain unknown. In this study, we …

SPP1+ macrophages have been identified as key players in the colorectal cancer (CRC)
tumor microenvironment, but their function remains unclear. This study integrated single-cell …