ABSTRACT In the United States alone, chronic wounds affect 6.5 million patients. It is
expected that the number of chronic wounds will increase worldwide due to the increase in …

Cutaneous wound healing is a vital biological process that aids skin regeneration upon
injury. Wound healing failure results from persistent inflammatory conditions observed in …

Background Wound healing is impaired in diabetes mellitus, but the mechanisms involved in
this process are virtually unknown. Proteins belonging to the insulin signaling pathway …

The PI3K/Akt pathway is necessary for several key endothelial cell (EC) functions, including
cell growth, migration, survival, and vascular tone. However, existing literature supports the …

Akt1 is implicated in cell metabolism, survival migration, and gene expression; however, little
is known about the role of specific Akt isoforms during inflammation in vivo. Thus, we directly …

The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma
(PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance …

Decades of research have elucidated the critical role of Akt isoforms in cancer as pro-
tumorigenic and metastatic regulators through their specific effects on the cancer cells, tumor …

Hyperphosphatemia is associated with increased cardiovascular risk in patients with renal
disease and in healthy individuals. Here we tested whether high phosphate has a role in the …

Impaired wound healing is a serious complication of diabetes that negatively affects the
patient's socioeconomic life. Multiple mechanisms contribute to impaired diabetic wound …

The signalling pathways operational in quiescent, post-development vasculature remain
enigmatic. Here we show that unlike neovascularization, endothelial Akt signalling in …