Astrocytes are key homeostatic and defensive cells of the central nervous system (CNS).
They undertake numerous functions during development and in adulthood to support and …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
impaired episodic memory and two pathological lesions: amyloid plaques and neurofibrillary …

Abstract The purinoceptor P2X 7 R is a promising therapeutic target for tauopathies,
including Alzheimer's disease (AD). Pharmacological inhibition or genetic knockdown of …

Background Over recent years, increasing evidence suggests a causal relationship between
neurofibrillary tangles (NFTs) formation, the main histopathological hallmark of tauopathies …

The P2X7 receptor (P2X7R), an ATP-gated ion channel, has emerged as a crucial player in
neuroinflammation and a promising therapeutic target for neurodegenerative disorders. This …

The purinergic pathway mediates both pro-inflammatory and anti-inflammatory responses,
whereas the breakdown of adenosine triphosphate (ATP) is in a critical equilibrium. Under …

Over the last few years, intense research efforts have been made to anticipate or improve
the diagnosis of Alzheimer's disease by detecting blood biomarkers. However, the most …

Introduction Astrocytes have previously been considered as cells supporting neuronal
functions, but they are now recognized as active players in maintaining central nervous …

Alzheimer's disease (AD) is a major cause of age-related dementia, which is becoming a
global health crisis. However, the pathogenesis and etiology of AD are still not fully …

Extensive evidence indicates that the activation of the P2X7 receptor (P2X7R), an ATP-
gated ion channel highly expressed in immune and brain cells, is strictly associated with the …