Gonadal hormone 17β-estradiol (E2) and its receptors are key regulators of gene
transcription by binding to estrogen responsive elements in the genome. Besides the …

Oxylipins, including the well-known eicosanoids, are potent lipid mediators involved in
numerous physiological and pathological processes. Therefore, their quantitative profiling …

Background: It has been estimated that a substantial portion of chronic and
noncommunicable diseases can be caused or exacerbated by exposure to environmental …

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is more common
in females. Despite its high global incidence, the disease mechanism is still unclear and …

Renal fibrosis is a common histomorphological feature of renal aging and chronic kidney
diseases of all etiologies, and its initiation and progression are substantially influenced by …

Preterm infants have immature organ functions that predispose them to gut and immune
disorders. Developmental delays at preterm birth may affect various organs differently at …

Pulmonary arterial hypertension (PAH) is a debilitating and progressive disease that
predominantly develops in women. Over the past 15 years, cumulating evidence has …

Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause
nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents …

Introduction Although the physiological role of the C-terminal hydrolase domain of the
soluble epoxide hydrolase (sEH-H) is well investigated, the function of its N-terminal …

The Western diet contains a high ratio of omega-6 (ω6) to omega-3 (ω3) polyunsaturated
fatty acids (PUFA). The prototypical aryl hydrocarbon receptor (AHR) ligand, 2, 3, 7, 8 …