Estradiol-induced epigenetically mediated mechanisms and regulation of gene expression
Gonadal hormone 17β-estradiol (E2) and its receptors are key regulators of gene
transcription by binding to estrogen responsive elements in the genome. Besides the …
transcription by binding to estrogen responsive elements in the genome. Besides the …
MS-based targeted metabolomics of eicosanoids and other oxylipins: Analytical and inter-individual variabilities
Oxylipins, including the well-known eicosanoids, are potent lipid mediators involved in
numerous physiological and pathological processes. Therefore, their quantitative profiling …
numerous physiological and pathological processes. Therefore, their quantitative profiling …
The promises and challenges of toxico-epigenomics: environmental chemicals and their impacts on the epigenome
Background: It has been estimated that a substantial portion of chronic and
noncommunicable diseases can be caused or exacerbated by exposure to environmental …
noncommunicable diseases can be caused or exacerbated by exposure to environmental …
Sex-bias in irritable bowel syndrome: linking steroids to the gut-brain axis
SY So, TC Savidge - Frontiers in Endocrinology, 2021 - frontiersin.org
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is more common
in females. Despite its high global incidence, the disease mechanism is still unclear and …
in females. Despite its high global incidence, the disease mechanism is still unclear and …
Klotho recovery by genistein via promoter histone acetylation and DNA demethylation mitigates renal fibrosis in mice
Y Li, F Chen, A Wei, F Bi, X Zhu, S Yin, W Lin… - Journal of Molecular …, 2019 - Springer
Renal fibrosis is a common histomorphological feature of renal aging and chronic kidney
diseases of all etiologies, and its initiation and progression are substantially influenced by …
diseases of all etiologies, and its initiation and progression are substantially influenced by …
Neonatal gut and immune maturation is determined more by postnatal age than by postconceptional age in moderately preterm pigs
Preterm infants have immature organ functions that predispose them to gut and immune
disorders. Developmental delays at preterm birth may affect various organs differently at …
disorders. Developmental delays at preterm birth may affect various organs differently at …
Estradiol metabolism: crossroads in pulmonary arterial hypertension
SP Tofovic, EK Jackson - International journal of molecular sciences, 2019 - mdpi.com
Pulmonary arterial hypertension (PAH) is a debilitating and progressive disease that
predominantly develops in women. Over the past 15 years, cumulating evidence has …
predominantly develops in women. Over the past 15 years, cumulating evidence has …
Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice
Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause
nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents …
nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents …
CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury
M Leuillier, T Duflot, S Ménoret, H Messaoudi… - Journal of advanced …, 2023 - Elsevier
Introduction Although the physiological role of the C-terminal hydrolase domain of the
soluble epoxide hydrolase (sEH-H) is well investigated, the function of its N-terminal …
soluble epoxide hydrolase (sEH-H) is well investigated, the function of its N-terminal …
Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression
S Huerta-Yepez, A Tirado-Rodriguez… - Scientific reports, 2020 - nature.com
The Western diet contains a high ratio of omega-6 (ω6) to omega-3 (ω3) polyunsaturated
fatty acids (PUFA). The prototypical aryl hydrocarbon receptor (AHR) ligand, 2, 3, 7, 8 …
fatty acids (PUFA). The prototypical aryl hydrocarbon receptor (AHR) ligand, 2, 3, 7, 8 …