The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

Complex multicellular organisms require rapid and accurate transmission of information
among cells and tissues and tight coordination of distant functions. Electrical signals and …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Background—The KCNH2 or human ether-a-go-go related gene (hERG) encodes the Kv11.
1 α-subunit of the rapidly activating delayed rectifier K+ current (I Kr) in the heart. Type 2 …

It has been suggested that deficient protein trafficking to the cell membrane is the dominant
mechanism associated with type 2 Long QT syndrome (LQT2) caused by Kv11. 1 potassium …

Long QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has
provided a wealth of information about fundamental mechanisms underlying human cardiac …

Objective To determine the spectrum, frequency, and ethnic-specificity of channel variants in
the potassium channel genes implicated in congenital long QT syndrome (LQTS) among …

The mechanisms underlying normal and abnormal cardiac rhythms are complex and
incompletely understood. Through the study of uncommon inheritable arrhythmia …

Long QT syndrome (LQTS) is a cardiovascular disease characterized by QT interval
prolongation that can lead to sudden cardiac death. Many mutations with heterogeneous …