Faithful eucaryotic cell division requires spatio-temporal orchestration of multiple sequential
events. To ensure the dynamic nature of these molecular and morphological transitions, a …

Assembly of the CMG (CDC-45–MCM-2-7–GINS) helicase is the key regulated step during
eukaryotic DNA replication initiation. Until now, it was unclear whether metazoa require …

Replication stress (RS) is a characteristic state of cancer cells as they tend to exchange
precision of replication for fast proliferation and increased genomic instability. To overcome …

The ATR kinase, which coordinates cellular responses to DNA replication stress, is also
essential for the proliferation of normal unstressed cells. Although its role in the replication …

Cell cycle regulation is largely abnormal in cancers. Molecular understanding and
therapeutic targeting of the aberrant cell cycle are essential. Here, we identified that an …

Abstract p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP
family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs. p27 …

After fertilization, remodeling of the oocyte and sperm genomes is essential to convert these
highly differentiated and transcriptionally quiescent cells into early cleavage‐stage …

Collisions between transcribing RNA polymerases and DNA replication forks are disruptive.
The threat of collisions is particularly acute during the rapid early embryonic cell cycles of …

Abstract Background Family Genomoviridae was recently established, and only a few
mycoviruses have been described and characterized, and almost all of them (Sclerotinia …

The intricate vascular system of the kidneys supports body fluid and organ homeostasis.
However, little is known about how vascular architecture is established during kidney …