Baicalein as promising anticancer agent: A comprehensive analysis on molecular mechanisms and therapeutic perspectives

AKMH Morshed, S Paul, A Hossain, T Basak… - Cancers, 2023 - mdpi.com
Simple Summary Cancer is a multifactorial disease characterized by excessive cell
proliferation in a specific organ. The most common treatments include chemotherapy …

Ethnopharmacologically important highly subsidized Indian medicinal plants: systematic review on their traditional uses, phytochemistry, pharmacology, quality control …

G Aggarwal, M Sharma, R Singh, U Sharma - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance India has an extensive reservoir of traditional wisdom and
a diverse range of medicinal plants that enrich its heritage. Plants have actively been used …

Baicalein potentiated M1 macrophage polarization in cancer through targeting PI3Kγ/NF-κB signaling

S He, S Wang, S Liu, Z Li, X Liu, J Wu - Frontiers in pharmacology, 2021 - frontiersin.org
Baicalein is one of the bioactive compounds extracted from Scutellaria baicalensis. Recent
studies indicated the antitumor effects of baicalein, however, the underlying mechanisms are …

Ethnobotanical study of medicinal plants used by the indigenous community of the western region of Mizoram, India

L Ralte, H Sailo, YT Singh - Journal of Ethnobiology and Ethnomedicine, 2024 - Springer
Background Plants have long been utilized as traditional medicines by the inhabitants.
However, until recently, the traditional knowledge had not been extensively documented …

Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke

Y Luan, E Huang, J Huang, Z Yang, Z Zhou… - Journal of translational …, 2023 - degruyter.com
Abstract Background and Objectives Myoglobin released by rhabdomyolysis (RM) is
considered to be involved in pathogenesis of kidney disease caused by crush injury, but …

Baicalein suppresses NLRP3 and AIM2 inflammasome-mediated pyroptosis in macrophages infected by Mycobacterium tuberculosis via induced autophagy

B Ning, J Shen, F Liu, H Zhang, X Jiang - Microbiology Spectrum, 2023 - Am Soc Microbiol
Mycobacterium tuberculosis (Mtb) continues to pose a significant threat to global health
because it causes granulomas and systemic inflammatory responses during active …

Nano-baicalein facilitates chemotherapy in breast cancer by targeting tumor microenvironment

F Zheng, Y Luo, Y Liu, Y Gao, W Chen, K Wei - International Journal of …, 2023 - Elsevier
Cancer-associated fibroblasts constitute a significant component in the tumor
microenvironment, playing a pivotal role in tumor proliferation, invasion, migration, and …

Traditional herbal medicine discovery for the treatment and prevention of pulmonary arterial hypertension

Z Xue, Y Li, M Zhou, Z Liu, G Fan, X Wang… - Frontiers in …, 2021 - frontiersin.org
Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery remodeling that
may subsequently culminate in right heart failure and premature death. Although there are …

Synergistic combination of baicalein and rifampicin against Staphylococcus aureus biofilms

R Muniyasamy, I Manjubala - Frontiers in Microbiology, 2024 - frontiersin.org
Staphylococcus aureus, a Gram-positive bacterium, is a predominant pathogen associated
with various infections. The rapid emergence of antibiotic resistance has intensified the …

[HTML][HTML] Bioactive compounds from nature: Antioxidants targeting cellular transformation in response to epigenetic perturbations induced by oxidative stress

A Bouyahya, S Bakrim, S Aboulaghras… - Biomedicine & …, 2024 - Elsevier
Oxidative stress results from a persistent imbalance in oxidation levels that promotes
oxidants, playing a crucial role in the early and sustained phases of DNA damage and …