Ten years after the first overview of a complete plant Hsf family was presented for
Arabidopsis thaliana by Nover et al.[1], we compiled data for 252 Hsfs from nine plant …

Proteins generally must fold into precise three-dimensional conformations to fulfill their
biological functions. In the cell, this fundamental process is aided by molecular chaperones …

The conserved transcriptional regulator heat shock factor 1 (Hsf1) is a key sensor of
proteotoxic and other stress in the eukaryotic cytosol. We surveyed Hsf1 activity in a genome …

Dynamic posttranslational modification of serine and threonine residues of
nucleocytoplasmic proteins by β-N-acetylglucosamine (O-GlcNAc) is a regulator of cellular …

Nuclear stress bodies (nSBs) are unique subnuclear organelles which form in response to
heat shock. They are initiated through a direct interaction between heat shock transcription …

The notion that phenotypic traits emerging from environmental experiences are heritable
remains under debate. However, the recent report of nonmendelian transgenerational …

All living organisms are constantly exposed to stresses from internal biological processes
and surrounding environments, which induce many adaptive changes in cellular physiology …

The molecular chaperone Hsp90 is one component of a highly complex and interactive
cellular proteostasis network (PN) that participates in protein folding, directs misfolded and …

Huntington disease (HD) is a devastating neurodegenerative disorder for which there are no
disease-modifying treatments. Previous studies have proposed that activation of the heat …

HSF1 (heat shock factor 1) is an evolutionarily conserved master transcriptional regulator of
the heat shock response (HSR) in eukaryotic cells. In response to high temperatures, HSF1 …