Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice

RS Wallis, M Pai, D Menzies, TM Doherty, G Walzl… - The lancet, 2010 - thelancet.com
Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis …

Point-of-care detection of lipoarabinomannan (LAM) in urine for diagnosis of HIV-associated tuberculosis: a state of the art review

SD Lawn - BMC infectious diseases, 2012 - Springer
Detection of Mycobacterium tuberculosis antigens in urine is attractive as a potential means
of diagnosing tuberculosis (TB) regardless of the anatomical site of disease. The most …

Facing the crisis: improving the diagnosis of tuberculosis in the HIV era

MD Perkins, J Cunningham - The Journal of infectious diseases, 2007 - academic.oup.com
Although the human immunodeficiency virus (HIV) infection pandemic has had a
catastrophic impact on tuberculosis (TB) control efforts, especially in sub-Saharan Africa …

The prognosis of latent tuberculosis: can disease be predicted?

P Andersen, TM Doherty, M Pai, K Weldingh - Trends in molecular …, 2007 - cell.com
In humans, Mycobacterium tuberculosis persists for long periods in a clinically latent state,
creating a huge reservoir of'silent'tuberculosis (TB)(roughly one-third of the global …

Biomarkers for tuberculosis disease activity, cure, and relapse

RS Wallis, TM Doherty, P Onyebujoh… - The Lancet infectious …, 2009 - thelancet.com
New drugs, vaccines, and other therapies will be required to realise the goal of global
tuberculosis elimination or control. This Review covers the important role biomarkers can …

Detection of lipoarabinomannan (LAM) in urine is an independent predictor of mortality risk in patients receiving treatment for HIV-associated tuberculosis in sub …

A Gupta-Wright, JA Peters, C Flach, SD Lawn - BMC medicine, 2016 - Springer
Background Simple immune capture assays that detect mycobacterial lipoarabinomannan
(LAM) antigen in urine are promising new tools for the diagnosis of HIV-associated …

Adjunctive tests for diagnosis of tuberculosis: serology, ELISPOT for site-specific lymphocytes, urinary lipoarabinomannan, string test, and fine needle aspiration

JM Achkar, SD Lawn, MYS Moosa… - Journal of Infectious …, 2011 - academic.oup.com
The diagnostic gold standard for active tuberculosis (TB) is the detection of Mycobacterium
tuberculosis (MTB) by culture or molecular methods. However, despite its limited sensitivity …

Sandwich electrochemical immunosensor for early detection of tuberculosis based on graphene/polyaniline-modified screen-printed gold electrode

UZ Mohd Azmi, NA Yusof, N Kusnin, J Abdullah… - Sensors, 2018 - mdpi.com
A rapid and sensitive sandwich electrochemical immunosensor was developed based on
the fabrication of the graphene/polyaniline (GP/PANI) nanocomposite onto screen-printed …

Immunosensor for Mycobacterium tuberculosis on screen-printed carbon electrodes

M Díaz-González, MB González-García… - Biosensors and …, 2005 - Elsevier
In this work, two methods have been compared to produce enzymatic voltammetric
immunosensors for the determination of Mycobacterium tuberculosis antigens (Ag360 and …

[HTML][HTML] Novel potential serological prostate cancer biomarkers using CT100+ cancer antigen microarray platform in a multi-cultural South African cohort

HA Adeola, M Smith, L Kaestner, JM Blackburn… - Oncotarget, 2016 - ncbi.nlm.nih.gov
There is a growing need for high throughput diagnostic tools for early diagnosis and
treatment monitoring of prostate cancer (PCa) in Africa. The role of cancer-testis antigens …