Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

Among the various bacterial infections, tuberculosis continues to hold center stage. Its
causative agent, Mycobacterium tuberculosis, possesses robust defense mechanisms …

Tuberculosis (TB) is the leading cause of death from a single infectious agent and in 2019
an estimated 10 million people worldwide contracted the disease. Although treatments for …

Tuberculosis has been the communicable disease being one of the top 10 causes of deaths
worldwide and the leading cause of deaths from a single infectious agent (ranking above …

Outside of Mycobacterium tuberculosis and Mycobacterium leprae, nontuberculous
mycobacteria (NTM) are environmental mycobacteria (> 190 species) and are classified as …

Mycobacteria species include a large number of pathogenic organisms such as
Mycobacterium tuberculosis, Mycobacterium leprae, and various non-tuberculous …

We performed a high-throughput phenotypic whole cell screen of Mycobacterium
tuberculosis against a diverse chemical library of approximately 100,000 compounds from …

Growing global demand for new molecules to treat tuberculosis has created an urgent need
to develop novel strategies to combat the menace. BM212 related compounds were found to …

Addressing drug resistance in Mycobacterium tuberculosis (Mtb) requires the development
of new drugs with new targets. We previously identified 13 MmpL3 inhibitors from a screen …

A series of molecules containing bulky lipophilic scaffolds was screened for activity against
Mycobacterium tuberculosis and a number of compounds with antimycobacterial activity …