Controlled human malaria infection: applications, advances, and challenges
Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …
PfEMP1–a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis
L Hviid, ATR Jensen - Advances in parasitology, 2015 - Elsevier
Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …
The human malaria parasite Plasmodium falciparum can sense environmental changes and respond by antigenic switching
VM Schneider, JE Visone, CT Harris… - Proceedings of the …, 2023 - National Acad Sciences
The primary antigenic and virulence determinant of the human malaria parasite Plasmodium
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …
Malaria: an overview
M Fikadu, E Ashenafi - Infection and Drug Resistance, 2023 - Taylor & Francis
Malaria is a global public health burden with an estimated 229 million cases reported
worldwide in 2019. About 94% of the reported cases were recorded in the African region …
worldwide in 2019. About 94% of the reported cases were recorded in the African region …
Differential Expression of var Gene Groups Is Associated with Morbidity Caused by Plasmodium falciparum Infection in Tanzanian Children
M Rottmann, T Lavstsen, JP Mugasa… - Infection and …, 2006 - Am Soc Microbiol
The var gene family of Plasmodium falciparum encodes the variant surface antigen
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 is considered …
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 is considered …
Systems biology of malaria explored with nonhuman primates
MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …
generations of scientists, since its debut in 1971, and remains pertinent to the present day …
Surface Co-Expression of Two Different PfEMP1 Antigens on Single Plasmodium falciparum-Infected Erythrocytes Facilitates Binding to ICAM1 and PECAM1
L Joergensen, DC Bengtsson, A Bengtsson… - PLoS …, 2010 - journals.plos.org
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play a
major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to …
major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to …
Safety and Clinical Outcome of Experimental Challenge of Human Volunteers with Plasmodium falciparum-Infected Mosquitoes: An Update
JE Epstein, S Rao, F Williams, D Freilich… - The Journal of …, 2007 - academic.oup.com
Background. Challenge of volunteers by the bites of membrane-fed anopheline mosquitoes
infected with Plasmodium falciparum was reported in 1986. In 1997, an analysis of …
infected with Plasmodium falciparum was reported in 1986. In 1997, an analysis of …
Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains
The binding of erythrocytes infected with mature blood stage parasites to the vascular bed is
key to the pathogenesis of malignant malaria. The binding is mediated by members of …
key to the pathogenesis of malignant malaria. The binding is mediated by members of …
Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and
host in shaping disease severity remains unclear. We explored the interaction between …
host in shaping disease severity remains unclear. We explored the interaction between …