Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

The ascendancy of metallo-β-lactamases within the clinical sector, while not ubiquitous, has
nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant …

The simplistic image of the bacterium as an isolated, planktonic, self-cloning automaton is
refuted. We now recognize bacteria as microorganisms of enormous diversity and …

Abstract β-lactams have a long history in the treatment of infectious diseases, though their
use has been and continues to be confounded by the development of resistance in target …

Dynamic combinatorial chemistry (DCC) has emerged as a powerful strategy to identify
ligands for biological targets given that it enables the target to direct the synthesis and …

Fructose 1, 6-bisphosphate aldolase is a ubiquitous cytosolic enzyme that catalyzes the
fourth step of glycolysis. Aldolases are classified into three groups: Class-I, Class-IA, and …

Abstract Bacteria carrying New Delhi metallo-β-lactamase-1 (New Delhi metallo-β-
lactamase, NDM-1) resistance gene is a new type of “superbug”, which can hydrolyze …

The emergence of metallo-β-lactamase (MBL)-producing isolates is a challenge to routine
microbiology laboratories, since there are no standardized methods for detecting such …

The use of β-lactam antibiotics is compromised by resistance, which is provided by β-
lactamases belonging to both metallo (MBL)-and serine (SBL)-β-lactamase subfamilies. The …

Catalytic semihydrogenation of internal alkynes using H2 is an attractive atom-economical
route to various alkenes, and its stereocontrol has received widespread attention, both in …