Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

Background This is an overview of the mechanisms of obesity and its relation to
cardiovascular risks, describing the available treatment options to manage this condition …

Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

The prevalence of obesity-related glomerulopathy is increasing in parallel with the
worldwide obesity epidemic. Glomerular hypertrophy and adaptive focal segmental …

Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Obesity represents the single most important risk factor for early disability and death in
developed societies, and the incidence of obesity remains at staggering levels. CNS …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption
causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million …

Primary hypertension is the dominant form of arterial hypertension in adolescents. Disturbed
body composition with, among other things, increased visceral fat deposition, accelerated …