Stress granules and neurodegeneration
Recent advances suggest that the response of RNA metabolism to stress has an important
role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral …
role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral …
[HTML][HTML] Liquid-liquid phase separation of TDP-43 and FUS in physiology and pathology of neurodegenerative diseases
JL Carey, L Guo - Frontiers in molecular biosciences, 2022 - frontiersin.org
Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous
membraneless organelles with essential cellular function. However, aberrant phase …
membraneless organelles with essential cellular function. However, aberrant phase …
[HTML][HTML] G3BP1 is a tunable switch that triggers phase separation to assemble stress granules
The mechanisms underlying ribonucleoprotein (RNP) granule assembly, including the basis
for establishing and maintaining RNP granules with distinct composition, are unknown. One …
for establishing and maintaining RNP granules with distinct composition, are unknown. One …
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner
INTRODUCTION Stress granules are dynamic structures composed of RNA and protein that
arise in the cytoplasm in response to a variety of stressors. These structures form via liquid …
arise in the cytoplasm in response to a variety of stressors. These structures form via liquid …
[HTML][HTML] The stress granule transcriptome reveals principles of mRNA accumulation in stress granules
Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress
granules are important in the stress response and may contribute to some degenerative …
granules are important in the stress response and may contribute to some degenerative …
[HTML][HTML] Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization
A Molliex, J Temirov, J Lee, M Coughlin, AP Kanagaraj… - Cell, 2015 - cell.com
Stress granules are membrane-less organelles composed of RNA-binding proteins (RBPs)
and RNA. Functional impairment of stress granules has been implicated in amyotrophic …
and RNA. Functional impairment of stress granules has been implicated in amyotrophic …
[HTML][HTML] Phase separation of C9orf72 dipeptide repeats perturbs stress granule dynamics
S Boeynaems, E Bogaert, D Kovacs, A Konijnenberg… - Molecular cell, 2017 - cell.com
Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in
the formation of multiple membrane-less organelles involved in RNA metabolism, including …
the formation of multiple membrane-less organelles involved in RNA metabolism, including …
[HTML][HTML] Stress granule assembly disrupts nucleocytoplasmic transport
Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a …
Ubiquitination is essential for recovery of cellular activities after heat shock
INTRODUCTION In response to many types of stress, eukaryotic cells initiate an adaptive
and reversible response that includes down-regulation of key cellular activities along with …
and reversible response that includes down-regulation of key cellular activities along with …
[HTML][HTML] Modulation of RNA condensation by the DEAD-box protein eIF4A
Stress granules are condensates of non-translating mRNAs and proteins involved in the
stress response and neurodegenerative diseases. Stress granules form in part through …
stress response and neurodegenerative diseases. Stress granules form in part through …