[HTML][HTML] Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases
Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …
SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice
FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …
Infectious diseases
Microglia, brain-resident innate immune cells, have been extensively studied in
neurodegenerative contexts like Alzheimer's disease. The Coronavirus disease 2019 …
neurodegenerative contexts like Alzheimer's disease. The Coronavirus disease 2019 …
Inflammasome activation and assembly in Huntington's disease
T de Oliveira Furlam, IG Roque, EWM da Silva… - Molecular …, 2022 - Elsevier
Huntington's disease (HD) is a rare neurodegenerative disease characterized by motor,
cognitive, and psychiatric symptoms. Inflammasomes are multiprotein complexes capable of …
cognitive, and psychiatric symptoms. Inflammasomes are multiprotein complexes capable of …
Ripks and Neuroinflammation
Y Xu, F Lin, G Liao, J Sun, W Chen, L Zhang - Molecular Neurobiology, 2024 - Springer
Neuroinflammation is an immune response in the central nervous system and poses a
significant threat to human health. Studies have shown that the receptor serine/threonine …
significant threat to human health. Studies have shown that the receptor serine/threonine …
Dihydroergotamine and Bromocriptine: Potential Drugs for the Treatment of Major Depressive Disorder and Alzheimer's Disease Comorbidity
M Fu, Q Wang, L Gao, Q Ma, J Wang - Molecular Neurobiology, 2024 - Springer
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease that is
characterized by memory loss and cognitive impairment. Evidence shows that depression is …
characterized by memory loss and cognitive impairment. Evidence shows that depression is …
Shedding light on microglial dysregulation in Alzheimer's disease: exploring molecular mechanisms and therapeutic avenues
V Bhardwaj, S Kumari, R Dhapola, P Sharma… - …, 2024 - Springer
Alzheimer's disease (AD) stands out as the foremost prevalent neurodegenerative disorder,
characterized by a complex etiology. Various mechanisms have been proposed to elucidate …
characterized by a complex etiology. Various mechanisms have been proposed to elucidate …
Effect of chronic cold stress on gut microbial diversity, intestinal inflammation and pyroptosis in mice
H Lv, S Xia, Y He, C Qiao, J Liu, J Guo, S Li - Journal of Physiology and …, 2024 - Springer
Hypothermia is an essential environmental factor in gastrointestinal diseases, but the main
molecular mechanisms of pathogenesis remain unclear. The current study sought to better …
molecular mechanisms of pathogenesis remain unclear. The current study sought to better …
Involvement of NLRP3 inflammasome pathway in the protective mechanisms of ferulic acid and p-coumaric acid in LPS-induced sickness behavior and …
Ferulic acid (FA) and p-coumaric acid (PCA) are abundantly present in commonly consumed
food and beverages. Being polyphenolic compounds, they have been explored for their …
food and beverages. Being polyphenolic compounds, they have been explored for their …
The role of quercetin in NLRP3-associated inflammation
J Wu, T Lv, Y Liu, Y Liu, Y Han, X Liu, X Peng… - …, 2024 - Springer
Quercetin is a natural flavonoid that is widely found in fruits and vegetables. As an important
flavonoid, it exhibits a wide range of biological activities, including antioxidant, anti …
flavonoid, it exhibits a wide range of biological activities, including antioxidant, anti …