[HTML][HTML] Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases

L Li, C Acioglu, RF Heary, S Elkabes - Brain, behavior, and immunity, 2021 - Elsevier
Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …

Infectious diseases

H Li, N Terrando, HA Gelbard - Microglia: Physiology, Pathophysiology …, 2024 - Springer
Microglia, brain-resident innate immune cells, have been extensively studied in
neurodegenerative contexts like Alzheimer's disease. The Coronavirus disease 2019 …

Inflammasome activation and assembly in Huntington's disease

T de Oliveira Furlam, IG Roque, EWM da Silva… - Molecular …, 2022 - Elsevier
Huntington's disease (HD) is a rare neurodegenerative disease characterized by motor,
cognitive, and psychiatric symptoms. Inflammasomes are multiprotein complexes capable of …

Ripks and Neuroinflammation

Y Xu, F Lin, G Liao, J Sun, W Chen, L Zhang - Molecular Neurobiology, 2024 - Springer
Neuroinflammation is an immune response in the central nervous system and poses a
significant threat to human health. Studies have shown that the receptor serine/threonine …

Dihydroergotamine and Bromocriptine: Potential Drugs for the Treatment of Major Depressive Disorder and Alzheimer's Disease Comorbidity

M Fu, Q Wang, L Gao, Q Ma, J Wang - Molecular Neurobiology, 2024 - Springer
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease that is
characterized by memory loss and cognitive impairment. Evidence shows that depression is …

Shedding light on microglial dysregulation in Alzheimer's disease: exploring molecular mechanisms and therapeutic avenues

V Bhardwaj, S Kumari, R Dhapola, P Sharma… - …, 2024 - Springer
Alzheimer's disease (AD) stands out as the foremost prevalent neurodegenerative disorder,
characterized by a complex etiology. Various mechanisms have been proposed to elucidate …

Effect of chronic cold stress on gut microbial diversity, intestinal inflammation and pyroptosis in mice

H Lv, S Xia, Y He, C Qiao, J Liu, J Guo, S Li - Journal of Physiology and …, 2024 - Springer
Hypothermia is an essential environmental factor in gastrointestinal diseases, but the main
molecular mechanisms of pathogenesis remain unclear. The current study sought to better …

Involvement of NLRP3 inflammasome pathway in the protective mechanisms of ferulic acid and p-coumaric acid in LPS-induced sickness behavior and …

M Kinra, N Ranadive, M Nampoothiri, D Arora… - Naunyn-schmiedeberg's …, 2024 - Springer
Ferulic acid (FA) and p-coumaric acid (PCA) are abundantly present in commonly consumed
food and beverages. Being polyphenolic compounds, they have been explored for their …

The role of quercetin in NLRP3-associated inflammation

J Wu, T Lv, Y Liu, Y Liu, Y Han, X Liu, X Peng… - …, 2024 - Springer
Quercetin is a natural flavonoid that is widely found in fruits and vegetables. As an important
flavonoid, it exhibits a wide range of biological activities, including antioxidant, anti …